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- W2013669353 abstract "Many of the organ-specific autoimmune diseases affect endocrine organs. This is due to the fact that the organ-specific autoantigens are often hormones or enzymes specifically engaged in the synthetic pathways resulting in hormone production. Autoimmune endocrine diseases include type 1 diabetes, hypo- and hyperthyroidism, Addison's disease, hypoparathyroidism, and gonadal failure. These diseases may occur as a solitary immunological abnormality but often coincide as polyendocrine autoimmune diseases, indicating a common aetiology in the pathogenesis. Autoimmune endocrine diseases have complex genetic predispositions and they are closely associated to certain HLA haplotypes. In addition to HLA, other genes are known to regulate the disposition to autoimmunity. Only a few autoimmune diseases with a monogenic background are known. An example is a syndrome regulated by a single gene, namely APECED, an acronym for autoimmune polyendocrinopathy candidiasis ectodermal dystrophy, also known as autoimmune polyendocrinopathy syndrome type 1 (APS1). In this autosomal recessive disease, mutations in the AIRE (autoimmune regulator) gene cause organ-specific autoimmune destruction of several, mostly endocrine, tissues. This article reviews current knowledge of APECED and the AIRE gene behind this syndrome." @default.
- W2013669353 created "2016-06-24" @default.
- W2013669353 creator A5060554663 @default.
- W2013669353 creator A5067888978 @default.
- W2013669353 creator A5078185115 @default.
- W2013669353 creator A5087859369 @default.
- W2013669353 date "2004-02-06" @default.
- W2013669353 modified "2023-10-18" @default.
- W2013669353 title "Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity" @default.
- W2013669353 cites W116460816 @default.
- W2013669353 cites W1501286679 @default.
- W2013669353 cites W1555988808 @default.
- W2013669353 cites W1561092615 @default.
- W2013669353 cites W156897084 @default.
- W2013669353 cites W1589446607 @default.
- W2013669353 cites W1600116166 @default.
- W2013669353 cites W1624822079 @default.
- W2013669353 cites W1643706151 @default.
- W2013669353 cites W1671992173 @default.
- W2013669353 cites W1900657670 @default.
- W2013669353 cites W1922016811 @default.
- W2013669353 cites W1966952488 @default.
- W2013669353 cites W1969614224 @default.
- W2013669353 cites W1971185090 @default.
- W2013669353 cites W1974439470 @default.
- W2013669353 cites W1977451393 @default.
- W2013669353 cites W1981199287 @default.
- W2013669353 cites W1986454867 @default.
- W2013669353 cites W1988841577 @default.
- W2013669353 cites W1989755312 @default.
- W2013669353 cites W1990939350 @default.
- W2013669353 cites W1991556982 @default.
- W2013669353 cites W1993972592 @default.
- W2013669353 cites W1998212578 @default.
- W2013669353 cites W1998905180 @default.
- W2013669353 cites W2004282938 @default.
- W2013669353 cites W2004705005 @default.
- W2013669353 cites W2005496330 @default.
- W2013669353 cites W2011789977 @default.
- W2013669353 cites W2012100191 @default.
- W2013669353 cites W2012182642 @default.
- W2013669353 cites W2012477137 @default.
- W2013669353 cites W2016265097 @default.
- W2013669353 cites W2016413380 @default.
- W2013669353 cites W2017421022 @default.
- W2013669353 cites W2020227010 @default.
- W2013669353 cites W2024310422 @default.
- W2013669353 cites W2025929993 @default.
- W2013669353 cites W2028222510 @default.
- W2013669353 cites W2028393908 @default.
- W2013669353 cites W2029311197 @default.
- W2013669353 cites W2031529855 @default.
- W2013669353 cites W2034877810 @default.
- W2013669353 cites W2034937079 @default.
- W2013669353 cites W2039051100 @default.
- W2013669353 cites W2039449653 @default.
- W2013669353 cites W2041354260 @default.
- W2013669353 cites W2043150560 @default.
- W2013669353 cites W2047147604 @default.
- W2013669353 cites W2050040308 @default.
- W2013669353 cites W2051346727 @default.
- W2013669353 cites W2057650154 @default.
- W2013669353 cites W2060312395 @default.
- W2013669353 cites W2061507519 @default.
- W2013669353 cites W2063733110 @default.
- W2013669353 cites W2069664665 @default.
- W2013669353 cites W2078509644 @default.
- W2013669353 cites W2082966751 @default.
- W2013669353 cites W2083080708 @default.
- W2013669353 cites W2083737302 @default.
- W2013669353 cites W2085567045 @default.
- W2013669353 cites W2093705724 @default.
- W2013669353 cites W2095315030 @default.
- W2013669353 cites W2098256718 @default.
- W2013669353 cites W2106669376 @default.
- W2013669353 cites W2106850730 @default.
- W2013669353 cites W2109900674 @default.
- W2013669353 cites W2116886228 @default.
- W2013669353 cites W2117991365 @default.
- W2013669353 cites W2119438647 @default.
- W2013669353 cites W2121665730 @default.
- W2013669353 cites W2125286421 @default.
- W2013669353 cites W2125540086 @default.
- W2013669353 cites W2128857363 @default.
- W2013669353 cites W2130784093 @default.
- W2013669353 cites W2132511528 @default.
- W2013669353 cites W2133966414 @default.
- W2013669353 cites W2137468466 @default.
- W2013669353 cites W2138258453 @default.
- W2013669353 cites W2143241514 @default.
- W2013669353 cites W2143764182 @default.
- W2013669353 cites W2143937186 @default.
- W2013669353 cites W2144076108 @default.
- W2013669353 cites W2150004911 @default.
- W2013669353 cites W2154438445 @default.
- W2013669353 cites W2159359142 @default.
- W2013669353 cites W2165214298 @default.
- W2013669353 cites W2170947255 @default.