Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013704433> ?p ?o ?g. }
- W2013704433 endingPage "573" @default.
- W2013704433 startingPage "561" @default.
- W2013704433 abstract "Membrane fusion is an energy-consuming process that requires tight juxtaposition of two lipid bilayers. Little is known about how cells overcome energy barriers to bring their membranes together for fusion. Previously, we have shown that cell-cell fusion is an asymmetric process in which an attacking cell drills finger-like protrusions into the receiving cell to promote cell fusion. Here, we show that the receiving cell mounts a Myosin II (MyoII)-mediated mechanosensory response to its invasive fusion partner. MyoII acts as a mechanosensor, which directs its force-induced recruitment to the fusion site, and the mechanosensory response of MyoII is amplified by chemical signaling initiated by cell adhesion molecules. The accumulated MyoII, in turn, increases cortical tension and promotes fusion pore formation. We propose that the protrusive and resisting forces from fusion partners put the fusogenic synapse under high mechanical tension, which helps to overcome energy barriers for membrane apposition and drives cell membrane fusion." @default.
- W2013704433 created "2016-06-24" @default.
- W2013704433 creator A5012638603 @default.
- W2013704433 creator A5016113911 @default.
- W2013704433 creator A5034515056 @default.
- W2013704433 creator A5043296622 @default.
- W2013704433 creator A5045816528 @default.
- W2013704433 creator A5055433405 @default.
- W2013704433 creator A5057596349 @default.
- W2013704433 creator A5083778545 @default.
- W2013704433 creator A5084102341 @default.
- W2013704433 creator A5085372023 @default.
- W2013704433 creator A5088007604 @default.
- W2013704433 date "2015-03-01" @default.
- W2013704433 modified "2023-10-14" @default.
- W2013704433 title "Mechanical Tension Drives Cell Membrane Fusion" @default.
- W2013704433 cites W115650398 @default.
- W2013704433 cites W156424259 @default.
- W2013704433 cites W1586169243 @default.
- W2013704433 cites W163921547 @default.
- W2013704433 cites W1768818798 @default.
- W2013704433 cites W1965446103 @default.
- W2013704433 cites W1980755477 @default.
- W2013704433 cites W1983429592 @default.
- W2013704433 cites W1986130046 @default.
- W2013704433 cites W1986802403 @default.
- W2013704433 cites W1997012066 @default.
- W2013704433 cites W1997087774 @default.
- W2013704433 cites W1998279163 @default.
- W2013704433 cites W2005979670 @default.
- W2013704433 cites W2006689028 @default.
- W2013704433 cites W2008163521 @default.
- W2013704433 cites W2008324561 @default.
- W2013704433 cites W2009096009 @default.
- W2013704433 cites W2011233440 @default.
- W2013704433 cites W2021551044 @default.
- W2013704433 cites W2034211436 @default.
- W2013704433 cites W2038504202 @default.
- W2013704433 cites W2038526080 @default.
- W2013704433 cites W2040169304 @default.
- W2013704433 cites W2045393678 @default.
- W2013704433 cites W2048056271 @default.
- W2013704433 cites W2048465987 @default.
- W2013704433 cites W2050758778 @default.
- W2013704433 cites W2052783078 @default.
- W2013704433 cites W2069314092 @default.
- W2013704433 cites W2070333171 @default.
- W2013704433 cites W2071102178 @default.
- W2013704433 cites W2072183325 @default.
- W2013704433 cites W2073965063 @default.
- W2013704433 cites W2076282036 @default.
- W2013704433 cites W2089696931 @default.
- W2013704433 cites W2089973243 @default.
- W2013704433 cites W2091001172 @default.
- W2013704433 cites W2094470817 @default.
- W2013704433 cites W2098047064 @default.
- W2013704433 cites W2108472247 @default.
- W2013704433 cites W2114606496 @default.
- W2013704433 cites W2115657143 @default.
- W2013704433 cites W2117425975 @default.
- W2013704433 cites W2120593068 @default.
- W2013704433 cites W2121492835 @default.
- W2013704433 cites W2122401346 @default.
- W2013704433 cites W2131653836 @default.
- W2013704433 cites W2135779274 @default.
- W2013704433 cites W2138313400 @default.
- W2013704433 cites W2140606720 @default.
- W2013704433 cites W2142974078 @default.
- W2013704433 cites W2157811844 @default.
- W2013704433 cites W2157963288 @default.
- W2013704433 cites W2161851632 @default.
- W2013704433 cites W2165673443 @default.
- W2013704433 cites W2166346086 @default.
- W2013704433 cites W2167916132 @default.
- W2013704433 cites W2170755361 @default.
- W2013704433 cites W2181706898 @default.
- W2013704433 cites W2183111016 @default.
- W2013704433 cites W2414682765 @default.
- W2013704433 cites W2417735454 @default.
- W2013704433 doi "https://doi.org/10.1016/j.devcel.2015.01.005" @default.
- W2013704433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4357538" @default.
- W2013704433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25684354" @default.
- W2013704433 hasPublicationYear "2015" @default.
- W2013704433 type Work @default.
- W2013704433 sameAs 2013704433 @default.
- W2013704433 citedByCount "121" @default.
- W2013704433 countsByYear W20137044332015 @default.
- W2013704433 countsByYear W20137044332016 @default.
- W2013704433 countsByYear W20137044332017 @default.
- W2013704433 countsByYear W20137044332018 @default.
- W2013704433 countsByYear W20137044332019 @default.
- W2013704433 countsByYear W20137044332020 @default.
- W2013704433 countsByYear W20137044332021 @default.
- W2013704433 countsByYear W20137044332022 @default.
- W2013704433 countsByYear W20137044332023 @default.
- W2013704433 crossrefType "journal-article" @default.
- W2013704433 hasAuthorship W2013704433A5012638603 @default.
- W2013704433 hasAuthorship W2013704433A5016113911 @default.