FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013903929> ?p ?o ?g. }

• W2013903929 endingPage "1358" @default.
• W2013903929 startingPage "1355" @default.
• W2013903929 abstract "GABAARs [GABA (γ-aminobutyric acid) type-A receptors] are heteropentameric chloride-selective ligand-gated ion channels that mediate fast inhibition in the brain and are key therapeutic targets for benzodiazepines, barbiturates, neurosteroids and general anaesthetics. In the brain, most of the benzodiazepine-sensitive synaptic receptor subtypes are assembled from α1-3, β1-3 and γ2 subunits. Although it is evident that the pharmacological manipulation of GABAAR function can have profound effects on behaviour, the endogenous mechanisms that neurons use to promote sustained changes in the efficacy of neuronal inhibition remain to be documented. It is increasingly clear that GABAARs undergo significant rates of constitutive endocytosis and regulate recycling processes that can determine the efficacy of synaptic inhibition. Their endocytosis is regulated via the direct binding of specific endocytosis motifs within the intracellular domains of receptor β1-3and γ2 subunits to the clathrin adaptor protein AP2 (adaptor protein 2). These binding motifs contain major sites of both serine and tyrosine phosphorylation within GABAARs. Their phosphorylation can have dramatic effects on binding to AP2. In the present review, we evaluate the role that these phospho-dependent interactions play in regulating the construction of inhibitory synapses, efficacy of neuronal inhibition and neuronal structure." @default.
• W2013903929 created "2016-06-24" @default.
• W2013903929 creator A5020338130 @default.
• W2013903929 creator A5073000074 @default.
• W2013903929 date "2009-11-19" @default.
• W2013903929 modified "2023-09-27" @default.
• W2013903929 title "The role of GABAAR phosphorylation in the construction of inhibitory synapses and the efficacy of neuronal inhibition" @default.
• W2013903929 cites W1965334496 @default.
• W2013903929 cites W1968579780 @default.
• W2013903929 cites W1969301568 @default.
• W2013903929 cites W1974146730 @default.
• W2013903929 cites W1975658980 @default.
• W2013903929 cites W1987672004 @default.
• W2013903929 cites W1988749472 @default.
• W2013903929 cites W1990567359 @default.
• W2013903929 cites W2000087227 @default.
• W2013903929 cites W2001077044 @default.
• W2013903929 cites W2001162506 @default.
• W2013903929 cites W2002335162 @default.
• W2013903929 cites W2016321438 @default.
• W2013903929 cites W2022378061 @default.
• W2013903929 cites W2028981528 @default.
• W2013903929 cites W2031411421 @default.
• W2013903929 cites W2038457835 @default.
• W2013903929 cites W2049983745 @default.
• W2013903929 cites W2052093835 @default.
• W2013903929 cites W2052184294 @default.
• W2013903929 cites W2053500820 @default.
• W2013903929 cites W2060612467 @default.
• W2013903929 cites W2072771549 @default.
• W2013903929 cites W2082903545 @default.
• W2013903929 cites W2087715700 @default.
• W2013903929 cites W2089061656 @default.
• W2013903929 cites W2101235918 @default.
• W2013903929 cites W2102186066 @default.
• W2013903929 cites W2113971423 @default.
• W2013903929 cites W2143935409 @default.
• W2013903929 cites W2144230507 @default.
• W2013903929 cites W2148714108 @default.
• W2013903929 cites W2148939305 @default.
• W2013903929 cites W2168729369 @default.
• W2013903929 cites W2170136226 @default.
• W2013903929 doi "https://doi.org/10.1042/bst0371355" @default.
• W2013903929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2846645" @default.
• W2013903929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19909275" @default.
• W2013903929 hasPublicationYear "2009" @default.
• W2013903929 type Work @default.
• W2013903929 sameAs 2013903929 @default.
• W2013903929 citedByCount "41" @default.
• W2013903929 countsByYear W20139039292012 @default.
• W2013903929 countsByYear W20139039292013 @default.
• W2013903929 countsByYear W20139039292014 @default.
• W2013903929 countsByYear W20139039292015 @default.
• W2013903929 countsByYear W20139039292017 @default.
• W2013903929 countsByYear W20139039292018 @default.
• W2013903929 countsByYear W20139039292019 @default.
• W2013903929 countsByYear W20139039292020 @default.
• W2013903929 countsByYear W20139039292022 @default.
• W2013903929 crossrefType "journal-article" @default.
• W2013903929 hasAuthorship W2013903929A5020338130 @default.
• W2013903929 hasAuthorship W2013903929A5073000074 @default.
• W2013903929 hasBestOaLocation W20139039292 @default.
• W2013903929 hasConcept C11960822 @default.
• W2013903929 hasConcept C168258287 @default.
• W2013903929 hasConcept C169760540 @default.
• W2013903929 hasConcept C170493617 @default.
• W2013903929 hasConcept C17077164 @default.
• W2013903929 hasConcept C183786373 @default.
• W2013903929 hasConcept C185592680 @default.
• W2013903929 hasConcept C28005876 @default.
• W2013903929 hasConcept C55493867 @default.
• W2013903929 hasConcept C86803240 @default.
• W2013903929 hasConcept C95444343 @default.
• W2013903929 hasConceptScore W2013903929C11960822 @default.
• W2013903929 hasConceptScore W2013903929C168258287 @default.
• W2013903929 hasConceptScore W2013903929C169760540 @default.
• W2013903929 hasConceptScore W2013903929C170493617 @default.
• W2013903929 hasConceptScore W2013903929C17077164 @default.
• W2013903929 hasConceptScore W2013903929C183786373 @default.
• W2013903929 hasConceptScore W2013903929C185592680 @default.
• W2013903929 hasConceptScore W2013903929C28005876 @default.
• W2013903929 hasConceptScore W2013903929C55493867 @default.
• W2013903929 hasConceptScore W2013903929C86803240 @default.
• W2013903929 hasConceptScore W2013903929C95444343 @default.
• W2013903929 hasIssue "6" @default.
• W2013903929 hasLocation W20139039291 @default.
• W2013903929 hasLocation W20139039292 @default.
• W2013903929 hasLocation W20139039293 @default.
• W2013903929 hasLocation W20139039294 @default.
• W2013903929 hasOpenAccess W2013903929 @default.
• W2013903929 hasPrimaryLocation W20139039291 @default.
• W2013903929 hasRelatedWork W1968529751 @default.
• W2013903929 hasRelatedWork W1984628987 @default.
• W2013903929 hasRelatedWork W2029269187 @default.
• W2013903929 hasRelatedWork W2046987765 @default.
• W2013903929 hasRelatedWork W2078422320 @default.
• W2013903929 hasRelatedWork W2117125969 @default.
• W2013903929 hasRelatedWork W2142925367 @default.

• next