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• W2013996814 abstract "DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsSpecials DAO 106:129-138 (2013) - DOI: https://doi.org/10.3354/dao02635 Identification of an iron acquisition machinery in Flavobacterium columnare Lingyu Guan1,2,*, Javier Santander1,3,4,*, Melha Mellata1, Yuangxing Zhang2, Roy Curtiss 3rd1,3,** 1The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA 2State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, P R China 3School of Life Sciences, Arizona State University, Tempe, Arizona 85287, USA 4Present address: Center for Genomics and Bioinformatics, Nucleus for Interdisciplinary Biotechnology, Universidad Mayor, Chile *Contributed equally to this work.**Corresponding author. Email: rcurtiss@asu.edu ABSTRACT: Flavobacterium columnare, a fastidious Gram-negative pathogen and the causative agent of columnaris disease, is one of the most harmful pathogens in the freshwater fish-farming industry. Nevertheless the virulence mechanisms of F. columnare are not well understood. Bacterial iron uptake from the host during infection is an important mechanism of virulence. Here we identified and analyzed part of the iron uptake machinery of F. columnare. Under iron-limited conditions during in vitro growth, synthesis of an outer membrane protein of ~86 kDa was upregulated. This protein was identified as a TonB-dependent ferrichrome-iron receptor precursor (FhuA). Synthesis of siderophores in F. columnare was corroborated by chrome azurol S assays. A putative ferric uptake regulator (Fur) protein was also identified in the F. columnare genome. Structural analysis of the F. columnare Fur protein revealed that it was similar to Fur proteins involved in iron uptake regulation of other bacteria. Furthermore, Salmonella enterica serovar Typhimurium (S. Typhimurium) Δfur mutants were partially complemented by the F. columnare fur gene. We conclude that a siderophore-mediated iron uptake system exists in F. columnare, and fur from F. columnare could partially complement S. Typhimurium Δfur mutant. KEY WORDS: Flavobacterium columnare · Siderophore · FhuA · Fur · Iron uptake Full text in pdf format PreviousNextCite this article as: Guan L, Santander J, Mellata M, Zhang Y, Curtiss R 3rd (2013) Identification of an iron acquisition machinery in Flavobacterium columnare . Dis Aquat Org 106:129-138. https://doi.org/10.3354/dao02635 Export citation RSS - Facebook - Tweet - linkedIn Cited by Published in DAO Vol. 106, No. 2. Online publication date: October 11, 2013 Print ISSN: 0177-5103; Online ISSN: 1616-1580 Copyright © 2013 Inter-Research." @default.
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• W2013996814 title "Identification of an iron acquisition machinery in Flavobacterium columnare" @default.
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