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- W2014262736 endingPage "175" @default.
- W2014262736 startingPage "163" @default.
- W2014262736 abstract "Amylin (islet amyloid polypeptide) is a peptide synthesized principally in the b-cells of the pancreatic islets together with insulin and has actions as a hormone, growth factor, and modifier of behavior. As a hormone, amylin acts to modify gastric motility, renal resorption, and has metabolic actions. It is postulated that the principal function of amylin as a hormone is the activation of physiological processes associated with feeding. As a growth factor, amylin acts on bone cells, renal proximal tubular cells, and islet b-cells. Amylin has important targets in the brain that mediate its actions in the modification of behavior, including thirst and satiety. In man, amylin can form islet amyloid deposits, an event linked to the reduction of b-cell mass and loss of signal-secretion coupling. Recent evidence has defined a new role for monomeric amylin as a growth factor and regulator of b-cell mass that is postulated to be a key factor in pathophysiological processes that result in overt diabetes." @default.
- W2014262736 created "2016-06-24" @default.
- W2014262736 creator A5005851875 @default.
- W2014262736 creator A5023731071 @default.
- W2014262736 creator A5048460362 @default.
- W2014262736 creator A5081705050 @default.
- W2014262736 date "2003-01-01" @default.
- W2014262736 modified "2023-10-16" @default.
- W2014262736 title "Amylin in the Periphery" @default.
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