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• W2014367025 abstract "Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1–8), three bisabolenes (9–11), four flavonols (12–15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9α-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound." @default.
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• W2014367025 date "2006-05-01" @default.
• W2014367025 modified "2023-10-17" @default.
• W2014367025 title "Cytotoxic constituents of Achillea clavennae from Montenegro" @default.
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• W2014367025 doi "https://doi.org/10.1016/j.phytochem.2006.02.026" @default.
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