Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016028107> ?p ?o ?g. }
- W2016028107 endingPage "133" @default.
- W2016028107 startingPage "125" @default.
- W2016028107 abstract "Immunosuppressive membrane gangliosides are released by tumor cells and inhibit normal antigen presenting cell (APC) function. To better understand this process, we have studied the effect of gangliosides on lipopolysaccharide (LPS)-induced maturation of human dendritic cells (DCs). Immature DCs were generated in vitro from human peripheral blood monocytes and were exposed for 72 h to a highly purified ganglioside, G(D1a). During the last 24 h, LPS was added to effect maturation. As assessed by fluorescence activated cell sorting (FACS) analysis, incubation in 50 microM G(D1a) significantly blunted the LPS-induced maturation of the dendritic cells. The expected up-regulation of expression of the co-stimulatory molecules CD80 and CD86 was ablated and that of CD40 was reduced, as were surface CD83 expression and intracellular CD208 production. In addition, ganglioside pretreatment of DC markedly inhibited the allostimulatory capacity and partially prevented the down-regulation of FITC-dextran uptake characteristic of LPS-activated DC. Furthermore, ganglioside-exposed DC also evidenced a broad down-regulation of the cytokine release that is normally initiated by LPS exposure, i.e., there was no increase in IL-1 beta, IL-6, IL-10, IL-12, or tumor necrosis factor (TNF)-alpha release. That a common mechanism may underlie these defects was suggested by the finding that G(D1a) exposure of DC also inhibited the nuclear binding of NF-kappa B that is normally induced by LPS. These results suggest that tumor gangliosides may blunt the anti-tumor immune response in vivo by binding and interfering with dendritic cell maturation." @default.
- W2016028107 created "2016-06-24" @default.
- W2016028107 creator A5004624398 @default.
- W2016028107 creator A5030478161 @default.
- W2016028107 date "2002-12-01" @default.
- W2016028107 modified "2023-09-25" @default.
- W2016028107 title "Ganglioside GD1a impedes lipopolysaccharide-induced maturation of human dendritic cells" @default.
- W2016028107 cites W1493121209 @default.
- W2016028107 cites W1499902555 @default.
- W2016028107 cites W1568165627 @default.
- W2016028107 cites W1579010799 @default.
- W2016028107 cites W1594646606 @default.
- W2016028107 cites W1597435039 @default.
- W2016028107 cites W1607379937 @default.
- W2016028107 cites W1661544713 @default.
- W2016028107 cites W1894625176 @default.
- W2016028107 cites W1975562276 @default.
- W2016028107 cites W1977945339 @default.
- W2016028107 cites W1979292499 @default.
- W2016028107 cites W2017277017 @default.
- W2016028107 cites W2018718597 @default.
- W2016028107 cites W2049103865 @default.
- W2016028107 cites W2058575141 @default.
- W2016028107 cites W2070622323 @default.
- W2016028107 cites W2088571368 @default.
- W2016028107 cites W2096152012 @default.
- W2016028107 cites W2100200230 @default.
- W2016028107 cites W2100788806 @default.
- W2016028107 cites W2102857621 @default.
- W2016028107 cites W2106877484 @default.
- W2016028107 cites W2111695773 @default.
- W2016028107 cites W2112643590 @default.
- W2016028107 cites W2112690101 @default.
- W2016028107 cites W2116716017 @default.
- W2016028107 cites W2120212813 @default.
- W2016028107 cites W2124376809 @default.
- W2016028107 cites W2127404676 @default.
- W2016028107 cites W2131761283 @default.
- W2016028107 cites W2132552157 @default.
- W2016028107 cites W2141575322 @default.
- W2016028107 cites W2155229523 @default.
- W2016028107 cites W2177327503 @default.
- W2016028107 cites W2427880780 @default.
- W2016028107 doi "https://doi.org/10.1016/s0008-8749(03)00004-2" @default.
- W2016028107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12657247" @default.
- W2016028107 hasPublicationYear "2002" @default.
- W2016028107 type Work @default.
- W2016028107 sameAs 2016028107 @default.
- W2016028107 citedByCount "35" @default.
- W2016028107 countsByYear W20160281072013 @default.
- W2016028107 countsByYear W20160281072014 @default.
- W2016028107 countsByYear W20160281072015 @default.
- W2016028107 countsByYear W20160281072017 @default.
- W2016028107 countsByYear W20160281072018 @default.
- W2016028107 countsByYear W20160281072019 @default.
- W2016028107 countsByYear W20160281072022 @default.
- W2016028107 countsByYear W20160281072023 @default.
- W2016028107 crossrefType "journal-article" @default.
- W2016028107 hasAuthorship W2016028107A5004624398 @default.
- W2016028107 hasAuthorship W2016028107A5030478161 @default.
- W2016028107 hasConcept C153911025 @default.
- W2016028107 hasConcept C154317977 @default.
- W2016028107 hasConcept C17991360 @default.
- W2016028107 hasConcept C202751555 @default.
- W2016028107 hasConcept C203014093 @default.
- W2016028107 hasConcept C2776090121 @default.
- W2016028107 hasConcept C2777331542 @default.
- W2016028107 hasConcept C2778170410 @default.
- W2016028107 hasConcept C2778297628 @default.
- W2016028107 hasConcept C2778690821 @default.
- W2016028107 hasConcept C2778754761 @default.
- W2016028107 hasConcept C2781101188 @default.
- W2016028107 hasConcept C39347974 @default.
- W2016028107 hasConcept C55493867 @default.
- W2016028107 hasConcept C86803240 @default.
- W2016028107 hasConcept C8891405 @default.
- W2016028107 hasConcept C95444343 @default.
- W2016028107 hasConceptScore W2016028107C153911025 @default.
- W2016028107 hasConceptScore W2016028107C154317977 @default.
- W2016028107 hasConceptScore W2016028107C17991360 @default.
- W2016028107 hasConceptScore W2016028107C202751555 @default.
- W2016028107 hasConceptScore W2016028107C203014093 @default.
- W2016028107 hasConceptScore W2016028107C2776090121 @default.
- W2016028107 hasConceptScore W2016028107C2777331542 @default.
- W2016028107 hasConceptScore W2016028107C2778170410 @default.
- W2016028107 hasConceptScore W2016028107C2778297628 @default.
- W2016028107 hasConceptScore W2016028107C2778690821 @default.
- W2016028107 hasConceptScore W2016028107C2778754761 @default.
- W2016028107 hasConceptScore W2016028107C2781101188 @default.
- W2016028107 hasConceptScore W2016028107C39347974 @default.
- W2016028107 hasConceptScore W2016028107C55493867 @default.
- W2016028107 hasConceptScore W2016028107C86803240 @default.
- W2016028107 hasConceptScore W2016028107C8891405 @default.
- W2016028107 hasConceptScore W2016028107C95444343 @default.
- W2016028107 hasIssue "2" @default.
- W2016028107 hasLocation W20160281071 @default.
- W2016028107 hasLocation W20160281072 @default.
- W2016028107 hasOpenAccess W2016028107 @default.