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• W2016073455 abstract "The cytotoxicity of enalapril maleate (EN) in primary cultures of rat hepatocytes, at concentrations of 0.5 mM or greater, was measured by the release of lactate dehydrogenase (LDH) into the culture medium. Pretreatment of the hepatocytes with L-buthionine-(S,R)-sulfoximine (BSO) and diethyl maleate (DEM) potentiated the toxicity whereas N-acetyl-L-cysteine (NAC) provided protection. EN produced a dose-dependent reduction in intracellular glutathione (GSH) concentration. This was an early effect, apparent after only 1 h of exposure to the drug, whereas loss of cell viability occurred after 6-18 h. These results suggest that the mechanism of EN cytotoxicity involves a GSH-dependent detoxification pathway." @default.
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• W2016073455 date "1991-11-01" @default.
• W2016073455 modified "2023-09-26" @default.
• W2016073455 title "Enalapril cytotoxicity in primary cultures of rat hepatocytes. II. Role of glutathione" @default.
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• W2016073455 doi "https://doi.org/10.1016/0378-4274(91)90038-8" @default.
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