FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016983742> ?p ?o ?g. }

• W2016983742 endingPage "e27170" @default.
• W2016983742 startingPage "e27170" @default.
• W2016983742 abstract "The nucleus pulposus (NP) of the intervertebral disc functions to provide compressive load support in the spine, and contains cells that play a critical role in the generation and maintenance of this tissue. The NP cell population undergoes significant morphological and phenotypic changes during maturation and aging, transitioning from large, vacuolated immature cells arranged in cell clusters to a sparse population of smaller, isolated chondrocyte-like cells. These morphological and organizational changes appear to correlate with the first signs of degenerative changes within the intervertebral disc. The extracellular matrix of the immature NP is a soft, gelatinous material containing multiple laminin isoforms, features that are unique to the NP relative to other regions of the disc and that change with aging and degeneration. Based on this knowledge, we hypothesized that a soft, laminin-rich extracellular matrix environment would promote NP cell-cell interactions and phenotypes similar to those found in immature NP tissues. NP cells were isolated from porcine intervertebral discs and cultured in matrix environments of varying mechanical stiffness that were functionalized with various matrix ligands; cellular responses to periods of culture were assessed using quantitative measures of cell organization and phenotype. Results show that soft (<720 Pa), laminin-containing extracellular matrix substrates promote NP cell morphologies, cell-cell interactions, and proteoglycan production in vitro, and that this behavior is dependent upon both extracellular matrix ligand and substrate mechanical properties. These findings indicate that NP cell organization and phenotype may be highly sensitive to their surrounding extracellular matrix environment." @default.
• W2016983742 created "2016-06-24" @default.
• W2016983742 creator A5037277098 @default.
• W2016983742 creator A5043592888 @default.
• W2016983742 creator A5053646968 @default.
• W2016983742 creator A5082857859 @default.
• W2016983742 date "2011-11-07" @default.
• W2016983742 modified "2023-10-17" @default.
• W2016983742 title "Extracellular Matrix Ligand and Stiffness Modulate Immature Nucleus Pulposus Cell-Cell Interactions" @default.
• W2016983742 cites W143623202 @default.
• W2016983742 cites W147236455 @default.
• W2016983742 cites W1561594530 @default.
• W2016983742 cites W1659989665 @default.
• W2016983742 cites W1924119154 @default.
• W2016983742 cites W1963772254 @default.
• W2016983742 cites W1965024650 @default.
• W2016983742 cites W1965275473 @default.
• W2016983742 cites W1966814089 @default.
• W2016983742 cites W1966973660 @default.
• W2016983742 cites W1968369580 @default.
• W2016983742 cites W1969220955 @default.
• W2016983742 cites W1973089587 @default.
• W2016983742 cites W1974170815 @default.
• W2016983742 cites W1976883962 @default.
• W2016983742 cites W1991192053 @default.
• W2016983742 cites W1992647292 @default.
• W2016983742 cites W1996865823 @default.
• W2016983742 cites W1998470771 @default.
• W2016983742 cites W2002875720 @default.
• W2016983742 cites W2007828614 @default.
• W2016983742 cites W2008816730 @default.
• W2016983742 cites W2015648732 @default.
• W2016983742 cites W2024250498 @default.
• W2016983742 cites W2027600661 @default.
• W2016983742 cites W2027990128 @default.
• W2016983742 cites W2028368206 @default.
• W2016983742 cites W2028981877 @default.
• W2016983742 cites W2039055927 @default.
• W2016983742 cites W2043634767 @default.
• W2016983742 cites W2043994091 @default.
• W2016983742 cites W2049015255 @default.
• W2016983742 cites W2049081530 @default.
• W2016983742 cites W2050273631 @default.
• W2016983742 cites W2057061995 @default.
• W2016983742 cites W2057635936 @default.
• W2016983742 cites W2060861339 @default.
• W2016983742 cites W2063753069 @default.
• W2016983742 cites W2065289282 @default.
• W2016983742 cites W2065321635 @default.
• W2016983742 cites W2072751809 @default.
• W2016983742 cites W2076912870 @default.
• W2016983742 cites W2077679674 @default.
• W2016983742 cites W2079047427 @default.
• W2016983742 cites W2079113756 @default.
• W2016983742 cites W2081790518 @default.
• W2016983742 cites W2085338873 @default.
• W2016983742 cites W2087404711 @default.
• W2016983742 cites W2087805577 @default.
• W2016983742 cites W2091573615 @default.
• W2016983742 cites W2099052265 @default.
• W2016983742 cites W2102171639 @default.
• W2016983742 cites W2115780596 @default.
• W2016983742 cites W2117636006 @default.
• W2016983742 cites W2118000827 @default.
• W2016983742 cites W2129464501 @default.
• W2016983742 cites W2135073071 @default.
• W2016983742 cites W2135571525 @default.
• W2016983742 cites W2138383018 @default.
• W2016983742 cites W2139522359 @default.
• W2016983742 cites W2145539666 @default.
• W2016983742 cites W2169755701 @default.
• W2016983742 cites W2342571638 @default.
• W2016983742 doi "https://doi.org/10.1371/journal.pone.0027170" @default.
• W2016983742 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3210142" @default.
• W2016983742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22087260" @default.
• W2016983742 hasPublicationYear "2011" @default.
• W2016983742 type Work @default.
• W2016983742 sameAs 2016983742 @default.
• W2016983742 citedByCount "87" @default.
• W2016983742 countsByYear W20169837422012 @default.
• W2016983742 countsByYear W20169837422013 @default.
• W2016983742 countsByYear W20169837422014 @default.
• W2016983742 countsByYear W20169837422015 @default.
• W2016983742 countsByYear W20169837422016 @default.
• W2016983742 countsByYear W20169837422017 @default.
• W2016983742 countsByYear W20169837422018 @default.
• W2016983742 countsByYear W20169837422019 @default.
• W2016983742 countsByYear W20169837422020 @default.
• W2016983742 countsByYear W20169837422021 @default.
• W2016983742 countsByYear W20169837422022 @default.
• W2016983742 countsByYear W20169837422023 @default.
• W2016983742 crossrefType "journal-article" @default.
• W2016983742 hasAuthorship W2016983742A5037277098 @default.
• W2016983742 hasAuthorship W2016983742A5043592888 @default.
• W2016983742 hasAuthorship W2016983742A5053646968 @default.
• W2016983742 hasAuthorship W2016983742A5082857859 @default.
• W2016983742 hasBestOaLocation W20169837421 @default.
• W2016983742 hasConcept C105702510 @default.

• next