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• W2017191752 startingPage "85" @default.
• W2017191752 abstract "Azthreonam (SQ 26,776) is a synthetic monocyclic beta-lactam antimicrobial agent belonging to the monobactam family (Sykes et al., Nature [London] 291:489-491, 1981), members of which are characterized by having the 2-oxoazetidine-1-sulfonic acid moiety. Azthreonam exhibits a high degree of stability to beta-lactamases and is specifically active against aerobic gram-negative bacteria, including Pseudomonas aeruginosa. Its activity against these organisms was in general equal or superior to that observed with the third-generation cephalosporins, cefotaxime and ceftazidime. Like penicillins and cephalosporins, azthreonam interacts with essential penicillin-binding proteins of gram-negative bacteria. Azthreonam protected mice against experimental infections produced by a range of gram-negative bacteria, exhibiting efficacy comparable to that of cefotaxime and ceftazidime." @default.
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• W2017191752 date "1982-01-01" @default.
• W2017191752 modified "2023-10-03" @default.
• W2017191752 title "Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria" @default.
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• W2017191752 doi "https://doi.org/10.1128/aac.21.1.85" @default.
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