FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017199534> ?p ?o ?g. }

• W2017199534 endingPage "544" @default.
• W2017199534 startingPage "536" @default.
• W2017199534 abstract "Aberrations in epigenetic marks have been associated with aging of the brain while caloric restriction (CR) and upregulation of endogenous antioxidants have been suggested as tools to attenuate the aging process. We have recently observed age-related increases in levels of 5-methylcytidine (5-mC) and DNA methyltransferase 3a (Dnmt3a) in the mouse hippocampus. Most of those age-related changes in these epigenetically relevant markers were prevented by CR but not by transgenic overexpression of the endogenous antioxidant superoxide dismutase 1 (SOD1). As recent work has suggested a distinct role for hydroxymethylation in epigenetic regulation of gene expression in the brain, the current study investigated age-related changes of 5-hydroxymethylcytosine (5-hmC) in the mouse hippocampus, and furthermore tested whether CR and transgenic upregulation of SOD1 affected any age-related changes in 5-hmC. Immunohistochemical analyses of 5-hmC in 12- and 24-month-old wild-type and transgenic mice overexpressing SOD1, which were kept under either a control or a calorie restricted diet, revealed an increase of 5-hmC immunoreactivity occurring with aging in the hippocampal dentate gyrus, CA3 and CA1-2 regions. Moreover, CR, but not overexpression of SOD1, prevented the agerelated increase in the CA3 region. These findings indicate that the aging process in mice is connected with changes in epigenetic machinery in the hippocampus and suggest that CR acts by influencing epigenetic regulation. Keywords: Aging, epigenesis, epigenetics, DNA hydroxymethylation, 5-hydroxymethylcytosine, caloric restriction, antioxidants, superoxide dismutase (SOD), hippocampus." @default.
• W2017199534 created "2016-06-24" @default.
• W2017199534 creator A5004432345 @default.
• W2017199534 creator A5012526784 @default.
• W2017199534 creator A5024796415 @default.
• W2017199534 creator A5032232964 @default.
• W2017199534 creator A5055401844 @default.
• W2017199534 creator A5057109503 @default.
• W2017199534 creator A5073037534 @default.
• W2017199534 creator A5077726948 @default.
• W2017199534 creator A5087422318 @default.
• W2017199534 date "2012-05-02" @default.
• W2017199534 modified "2023-10-01" @default.
• W2017199534 title "Age-Related Increase in Levels of 5-Hydroxymethylcytosine in Mouse Hippocampus is Prevented by Caloric Restriction" @default.
• W2017199534 cites W10617300 @default.
• W2017199534 cites W1488124756 @default.
• W2017199534 cites W1673972395 @default.
• W2017199534 cites W17728192 @default.
• W2017199534 cites W1933788686 @default.
• W2017199534 cites W1965984435 @default.
• W2017199534 cites W1966132436 @default.
• W2017199534 cites W1968717432 @default.
• W2017199534 cites W1978255681 @default.
• W2017199534 cites W1979369962 @default.
• W2017199534 cites W1981463058 @default.
• W2017199534 cites W1982354720 @default.
• W2017199534 cites W1982647833 @default.
• W2017199534 cites W1984130135 @default.
• W2017199534 cites W1986909933 @default.
• W2017199534 cites W1988949532 @default.
• W2017199534 cites W1989457196 @default.
• W2017199534 cites W2002923287 @default.
• W2017199534 cites W2004984537 @default.
• W2017199534 cites W2009903752 @default.
• W2017199534 cites W2014623973 @default.
• W2017199534 cites W2017199287 @default.
• W2017199534 cites W2018419725 @default.
• W2017199534 cites W2020089910 @default.
• W2017199534 cites W2022077982 @default.
• W2017199534 cites W2023831571 @default.
• W2017199534 cites W2026255880 @default.
• W2017199534 cites W2027735953 @default.
• W2017199534 cites W2032882684 @default.
• W2017199534 cites W2033793502 @default.
• W2017199534 cites W2038756976 @default.
• W2017199534 cites W2041335853 @default.
• W2017199534 cites W2048823427 @default.
• W2017199534 cites W2050880607 @default.
• W2017199534 cites W2051692581 @default.
• W2017199534 cites W2053176849 @default.
• W2017199534 cites W2053901332 @default.
• W2017199534 cites W2063324016 @default.
• W2017199534 cites W2064861163 @default.
• W2017199534 cites W2064943181 @default.
• W2017199534 cites W2065635702 @default.
• W2017199534 cites W2066209507 @default.
• W2017199534 cites W2066430702 @default.
• W2017199534 cites W2068128042 @default.
• W2017199534 cites W2068244686 @default.
• W2017199534 cites W2077498681 @default.
• W2017199534 cites W2078397347 @default.
• W2017199534 cites W2082699423 @default.
• W2017199534 cites W2084792449 @default.
• W2017199534 cites W2093510885 @default.
• W2017199534 cites W2095146454 @default.
• W2017199534 cites W2097487849 @default.
• W2017199534 cites W2103486606 @default.
• W2017199534 cites W2108664872 @default.
• W2017199534 cites W2114926230 @default.
• W2017199534 cites W2115818350 @default.
• W2017199534 cites W2120626403 @default.
• W2017199534 cites W2121090755 @default.
• W2017199534 cites W2123007201 @default.
• W2017199534 cites W2123927456 @default.
• W2017199534 cites W2131408584 @default.
• W2017199534 cites W2133469113 @default.
• W2017199534 cites W2136575970 @default.
• W2017199534 cites W2137006779 @default.
• W2017199534 cites W2137983089 @default.
• W2017199534 cites W2144699106 @default.
• W2017199534 cites W2146301715 @default.
• W2017199534 cites W2146824244 @default.
• W2017199534 cites W2149591661 @default.
• W2017199534 cites W2152451432 @default.
• W2017199534 cites W2154064074 @default.
• W2017199534 cites W2156934560 @default.
• W2017199534 cites W2161326542 @default.
• W2017199534 cites W2170297938 @default.
• W2017199534 cites W2170891278 @default.
• W2017199534 doi "https://doi.org/10.2174/156720512800618035" @default.
• W2017199534 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3561726" @default.
• W2017199534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22272625" @default.
• W2017199534 hasPublicationYear "2012" @default.
• W2017199534 type Work @default.
• W2017199534 sameAs 2017199534 @default.
• W2017199534 citedByCount "79" @default.
• W2017199534 countsByYear W20171995342012 @default.
• W2017199534 countsByYear W20171995342013 @default.

• next