FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017351769> ?p ?o ?g. }

• W2017351769 abstract "Two types of bisphosphonates (BPs), incadronate (INC) and etidronate (ETI) accelerated phosphate (Pi)-primed mineralization of MC4 cells in a subnanomolar dose range. Intracellular signaling pathways involved were examined. 1) The effect of INC but not ETI was partially suppressed by two mevalonate (MVA) pathway metabolites, farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP). 2) The BP-like accelerating effect was produced by statins and also by Toxin B, a Rho GTPases-specific inhibitor. 3) INC induced Cbfa1-nuclear localization within hours; and in an in vivo experiment using ovariectomized mice, its 3 weeks dosing exhibited the same effect in tibial extracts. 4) BPs promoted luciferase expression in murine p1.3-osteocalcin gene 2-luc and p6-osteoblast specific element 2-luc transfected cells, just as MVA, FPP and GGPP did independently and additively to INC. 5) BPs activated extracellular signal-regulated kinase (ERK1/2) in a Ras-independent manner within 5 min, and Pi was found to sensitize MC4 cells to BPs. MVA and its metabolites also activated ERKs but in a Ras-dependent manner and additively to INC. Ras dependency was determined using N17Ras-transfected cells. A MEK (MAP kinase-ERK kinase)-specific inhibitor PD98059 alone partly and with FPP completely blocked INC-induced mineralization. The results suggest that BPs act on Pi-sensitized MC4 cells to accelerate mineralization via nonRas-MEK-ERK1/2-Cbfa1 transactivation pathway and INC additionally acts by inhibiting the MVA pathway." @default.
• W2017351769 created "2016-06-24" @default.
• W2017351769 creator A5007464002 @default.
• W2017351769 creator A5032088633 @default.
• W2017351769 creator A5035422071 @default.
• W2017351769 creator A5036953877 @default.
• W2017351769 creator A5072045638 @default.
• W2017351769 creator A5086292182 @default.
• W2017351769 creator A5090422481 @default.
• W2017351769 date "2001-01-01" @default.
• W2017351769 modified "2023-09-25" @default.
• W2017351769 title "Incadronate and Etidronate Accelerate Phosphate-Primed Mineralization of MC4 Cells via ERK1 /2-Cbfa1 Signaling Pathway in a Ras-Independent Manner: Further Involvement of Mevalonate-Pathway Blockade for Incadronate" @default.
• W2017351769 cites W125879246 @default.
• W2017351769 cites W1597787921 @default.
• W2017351769 cites W1873492158 @default.
• W2017351769 cites W1897499866 @default.
• W2017351769 cites W1966064911 @default.
• W2017351769 cites W1973052124 @default.
• W2017351769 cites W1975107690 @default.
• W2017351769 cites W1980337097 @default.
• W2017351769 cites W1982399354 @default.
• W2017351769 cites W1984131196 @default.
• W2017351769 cites W1987340701 @default.
• W2017351769 cites W1993243592 @default.
• W2017351769 cites W1994596418 @default.
• W2017351769 cites W1995911293 @default.
• W2017351769 cites W1997812904 @default.
• W2017351769 cites W2014737217 @default.
• W2017351769 cites W2020364703 @default.
• W2017351769 cites W2023781848 @default.
• W2017351769 cites W2024887507 @default.
• W2017351769 cites W2027168680 @default.
• W2017351769 cites W2031851347 @default.
• W2017351769 cites W2032991286 @default.
• W2017351769 cites W2034238658 @default.
• W2017351769 cites W2035373485 @default.
• W2017351769 cites W2035936653 @default.
• W2017351769 cites W2043759393 @default.
• W2017351769 cites W2049005188 @default.
• W2017351769 cites W2049760002 @default.
• W2017351769 cites W2051926344 @default.
• W2017351769 cites W2054616090 @default.
• W2017351769 cites W2062273595 @default.
• W2017351769 cites W2076107807 @default.
• W2017351769 cites W2083319499 @default.
• W2017351769 cites W2093101675 @default.
• W2017351769 cites W2093164779 @default.
• W2017351769 cites W2121551386 @default.
• W2017351769 cites W2153009489 @default.
• W2017351769 cites W2161837912 @default.
• W2017351769 cites W2167840876 @default.
• W2017351769 cites W2170680219 @default.
• W2017351769 cites W2321227665 @default.
• W2017351769 cites W2003865274 @default.
• W2017351769 doi "https://doi.org/10.1254/jjp.86.86" @default.
• W2017351769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11430477" @default.
• W2017351769 hasPublicationYear "2001" @default.
• W2017351769 type Work @default.
• W2017351769 sameAs 2017351769 @default.
• W2017351769 citedByCount "22" @default.
• W2017351769 countsByYear W20173517692014 @default.
• W2017351769 countsByYear W20173517692023 @default.
• W2017351769 crossrefType "journal-article" @default.
• W2017351769 hasAuthorship W2017351769A5007464002 @default.
• W2017351769 hasAuthorship W2017351769A5032088633 @default.
• W2017351769 hasAuthorship W2017351769A5035422071 @default.
• W2017351769 hasAuthorship W2017351769A5036953877 @default.
• W2017351769 hasAuthorship W2017351769A5072045638 @default.
• W2017351769 hasAuthorship W2017351769A5086292182 @default.
• W2017351769 hasAuthorship W2017351769A5090422481 @default.
• W2017351769 hasBestOaLocation W20173517691 @default.
• W2017351769 hasConcept C104317684 @default.
• W2017351769 hasConcept C1292079 @default.
• W2017351769 hasConcept C153911025 @default.
• W2017351769 hasConcept C184235292 @default.
• W2017351769 hasConcept C185592680 @default.
• W2017351769 hasConcept C202751555 @default.
• W2017351769 hasConcept C2778260815 @default.
• W2017351769 hasConcept C55493867 @default.
• W2017351769 hasConcept C57074206 @default.
• W2017351769 hasConcept C62478195 @default.
• W2017351769 hasConcept C86339819 @default.
• W2017351769 hasConcept C86803240 @default.
• W2017351769 hasConcept C95444343 @default.
• W2017351769 hasConcept C98274493 @default.
• W2017351769 hasConceptScore W2017351769C104317684 @default.
• W2017351769 hasConceptScore W2017351769C1292079 @default.
• W2017351769 hasConceptScore W2017351769C153911025 @default.
• W2017351769 hasConceptScore W2017351769C184235292 @default.
• W2017351769 hasConceptScore W2017351769C185592680 @default.
• W2017351769 hasConceptScore W2017351769C202751555 @default.
• W2017351769 hasConceptScore W2017351769C2778260815 @default.
• W2017351769 hasConceptScore W2017351769C55493867 @default.
• W2017351769 hasConceptScore W2017351769C57074206 @default.
• W2017351769 hasConceptScore W2017351769C62478195 @default.
• W2017351769 hasConceptScore W2017351769C86339819 @default.
• W2017351769 hasConceptScore W2017351769C86803240 @default.
• W2017351769 hasConceptScore W2017351769C95444343 @default.
• W2017351769 hasConceptScore W2017351769C98274493 @default.
• W2017351769 hasLocation W20173517691 @default.

• next