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• W2019247935 abstract "<b><i>Objective:</i></b> To assess a possible relationship between thyroid-stimulating hormone (TSH) levels, vascular risk factors, and Alzheimer disease (AD). <b><i>Methods:</i></b> TSH levels were measured in 178 AD patients (35 confirmed post mortem) and 291 cognitively screened control subjects who were all euthyroid (TSH: 0.5 to 6 mU/L). The risk of AD was determined in participants with lower levels of TSH, several cerebrovascular risk factors, and other potential confounds. <b><i>Results:</i></b> AD patients had significantly lower levels of TSH than control subjects. Lowered TSH was associated with a more than twofold increased risk of AD (odds ratio = 2.36, 95% CI = 1.19 to 4.67), independent of other risk factors. <b><i>Conclusion:</i></b> Lowered TSH within the normal range is a risk factor for AD, independent of several cerebrovascular risk factors and confounding variables." @default.
• W2019247935 created "2016-06-24" @default.
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• W2019247935 date "2004-06-07" @default.
• W2019247935 modified "2023-09-25" @default.
• W2019247935 title "Low thyroid-stimulating hormone as an independent risk factor for Alzheimer disease" @default.
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• W2019247935 doi "https://doi.org/10.1212/01.wnl.0000128134.84230.9f" @default.
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