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- W2019927207 abstract "The aim of this study was to differentiate the processing of nociceptive information, matched for pain intensity, from capsaicin-induced hyperalgesic vs. control skin at multiple levels in the trigeminal nociceptive pathway. Using an event-related fMRI approach, 12 male subjects underwent three functional scans beginning 1 h after topical application of capsaicin to a defined location on the maxillary skin, when pain from capsaicin application had completely subsided. Brush and two levels of painful heat (low—Thermal-1 and high—Thermal-2) were applied to the site of capsaicin application and to the mirror image region on the opposite side. Temperatures for each side were set to evoke perceptually matched pain (mean temperatures [capsaicin/control]: Thermal-1 = 38.4/42.8 °C; Thermal-2 = 44.9/47.8 °C). We found differences in activation patterns following stimuli to treated and untreated sides in sensory circuits across all stimulus conditions. Across the trigeminal nociceptive pathway, Thermal-2 stimulation of hyperalgesic skin evoked greater activation in trigeminal ganglion and nucleus, thalamus, and somatosensory cortex than the control side. Thus, trigeminal nociceptive regions showed increased activation in the context of perceptually equal pain levels. Beyond these regions, contrast analyses of capsaicin vs. control skin stimulation indicated significant changes in bilateral dorsolateral prefrontal cortex and amygdala. The involvement of these emotion-related regions suggests that they may be highly sensitive to context, such as prior experience (application of capsaicin) and the specific pain mechanism (hyperalgesic vs. normal skin)." @default.
- W2019927207 created "2016-06-24" @default.
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- W2019927207 date "2007-05-01" @default.
- W2019927207 modified "2023-10-14" @default.
- W2019927207 title "Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: An fMRI study" @default.
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- W2019927207 doi "https://doi.org/10.1016/j.neuroimage.2007.02.001" @default.
- W2019927207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2034350" @default.
- W2019927207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17407825" @default.