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• W2020199379 abstract "The genetic properties of the non-Mendelian element, [URE3], suggest that it is a prion (infectious protein) form of Ure2p, a mediator of nitrogen regulation in Saccharomyces cerevisiae. Into a ure2Delta strain (necessarily lacking [URE3]), we introduced a plasmid overproducing Ure2p. This induced the frequent spontaneous generation of [URE3], with properties identical to the original [URE3]. Altering the translational frame only in the prion-inducing domain of URE2 shows that it is Ure2 protein (and not URE2 RNA) that induces appearance of [URE3]. The proteinase K-resistance of Ure2p is unique to [URE3] strains and is not seen in nitrogen regulation of normal strains. The prion-inducing domain of Ure2p (residues 1-65) can propagate [URE3] in the absence of the C-terminal part of the molecule. In contrast, the C-terminal part of Ure2p cannot be converted to the prion (inactive) form without the prion-inducing domain covalently attached. These experiments support the prion model for [URE3] and extend our understanding of its propagation." @default.
• W2020199379 created "2016-06-24" @default.
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• W2020199379 date "1997-11-11" @default.
• W2020199379 modified "2023-10-02" @default.
• W2020199379 title "The prion model for [URE3] of yeast: Spontaneous generation and requirements for propagation" @default.
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• W2020199379 doi "https://doi.org/10.1073/pnas.94.23.12503" @default.
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