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• W2020598009 abstract "<b>Background:</b> The emergence of antimalarial drug resistance malaria parasite is widespread in North eastern region of India. During January 2012-December 2013, we conducted active surveillance for detection of antifolate resistance-associated genetic polymorphisms in <i>Plasmodium falciparum</i> malaria parasite from different malaria endemic areas of Assam. <b>Materials and Methods:</b> A total of 281 field samples were collected from suspected malaria patients of which 106 malaria <i>P. falciparum</i> positive cases were detected in microscopic slide examination. A nested PCR was done for amplification of a 648 bp portion of the <i>dhfr</i> gene and 710 bp portion of the <i>dhps</i> gene. <b>Results:</b> Mutation analysis revealed existence of three different haplotypes of the <i>P. falciparum dhfr</i> gene of which ANRNI was highly prevalent (90%). Triple mutant haplotypes AIRNI (N51I + C59R + S108N) of the <i>dhfr</i> gene associated with pyrimethamine resistance were prevalent in Chirang district of Assam. Whereas, <i>dhps</i> mutation study revealed that triple mutant haplotype AGEAA (S436A + A437G + K540E) associated with Sulphadoxine resistance was found among 26% of <i>P. falciparum</i> field isolates. However, <i>P. falciparum dhfr-dhps</i> two locus mutation analysis showed that there were a total of nine <i>dhfr-dhps</i> genotypes. <b>Conclusion:</b> It was noticed that 93.62% (88/94) isolates had mutations in the sequences of both enzymes, which is an indication of prevalence of high grade of Sulphadoxine - pyrimethamine resistance in <i>P. falciparum</i> malaria parasites in Assam." @default.
• W2020598009 created "2016-06-24" @default.
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• W2020598009 date "2015-01-01" @default.
• W2020598009 modified "2023-10-09" @default.
• W2020598009 title "Genetic polymorphisms associated with sulphadoxine-pyrimethamine drug resistance among Plasmodium falciparum field isolates in malaria endemic areas of Assam" @default.
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• W2020598009 doi "https://doi.org/10.4103/0022-3859.147019" @default.
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