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• W2022070851 startingPage "1161" @default.
• W2022070851 abstract "Abstract Aging in mice and humans is characterized by declining T-lymphocyte production in the thymus, yet it is unclear whether aging impacts the T-lineage potential of hematopoietic progenitors. Although alterations in the lymphoid progenitor content of aged mouse bone marrow (BM) have been described, irradiation-reconstitution experiments have failed to reveal defects in T-lineage potential of BM hematopoietic progenitors or purified hematopoietic stem cells (HSCs) from aged mice. Here, we assessed T-progenitor potential in unmanipulated recipient mice without conditioning irradiation. T-progenitor potential was reduced in aged BM compared with young BM, and this reduction was apparent at the earliest stages of intrathymic differentiation. Further, enriched populations of aged HSCs or multipotent progenitors (MPPs) gave rise to fewer T-lineage cells than their young counterparts. Whereas the T-precursor frequency within the MPP pool was unchanged, there was a 4-fold decline in T-precursor frequency within the HSC pool. In addition, among the T-competent HSC clones, there were fewer highly proliferative clones in the aged HSC pool than in the young HSC pool. These results identify T-compromised aged HSCs and define the nature and cellular sites of prethymic, age-related defects in T-lineage differentiation potential." @default.
• W2022070851 created "2016-06-24" @default.
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• W2022070851 date "2007-08-15" @default.
• W2022070851 modified "2023-10-01" @default.
• W2022070851 title "Multiple prethymic defects underlie age-related loss of T progenitor competence" @default.
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• W2022070851 doi "https://doi.org/10.1182/blood-2007-01-071605" @default.
• W2022070851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1939899" @default.
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