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• W2022207186 abstract "The design, synthesis and structure–activity relationship studies of a novel series of CRF-1 receptor antagonists, the 2-arylpyrimidines, are described. The effects of substitution on the aromatic ring and the pyrimidine core on CRF-1 receptor binding were investigated. A number of compounds with Ki values below 10 nM and lipophilicity in a minimally acceptable range for a CNS drug (cLog P < 5) were discovered." @default.
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• W2022207186 date "2008-08-01" @default.
• W2022207186 modified "2023-09-22" @default.
• W2022207186 title "2-Arylpyrimidines: Novel CRF-1 receptor antagonists" @default.
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• W2022207186 doi "https://doi.org/10.1016/j.bmcl.2008.07.063" @default.
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