Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022807604> ?p ?o ?g. }
- W2022807604 abstract "CCAAT/Enhancer Binding Proteins (C/EBPs) play pivotal roles in the development and plasticity of the nervous system. Identification of the physiological targets of C/EBPs (C/EBP target genes) should therefore provide insight into the underlying biology of these processes. We used unbiased genome-wide mapping to identify 115 C/EBPbeta target genes in PC12 cells that include transcription factors, neurotransmitter receptors, ion channels, protein kinases and synaptic vesicle proteins. C/EBPbeta binding sites were located primarily within introns, suggesting novel regulatory functions, and were associated with binding sites for other developmentally important transcription factors. Experiments using dominant negatives showed C/EBPbeta to repress transcription of a subset of target genes. Target genes in rat brain were subsequently found to preferentially bind C/EBPalpha, beta and delta. Analysis of the hippocampal transcriptome of C/EBPbeta knockout mice revealed dysregulation of a high percentage of transcripts identified as C/EBP target genes. These results support the hypothesis that C/EBPs play non-redundant roles in the brain." @default.
- W2022807604 created "2016-06-24" @default.
- W2022807604 creator A5052818579 @default.
- W2022807604 creator A5077565874 @default.
- W2022807604 date "2009-03-01" @default.
- W2022807604 modified "2023-09-26" @default.
- W2022807604 title "Identification of neuronal target genes for CCAAT/enhancer binding proteins." @default.
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