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- W2024100063 abstract "The genetically and congenitally athymic ‘nude’ mouse has become useful material in several fields of study. Firstly, the thymus governs the mechanisms of rejection of foreign grafts and the level of antibody production. Classical procedures of extirpation and implantation have been extremely fruitful, but the persistence in the circulation of thymus-derived cells creates some uncertainties. The ‘nude’ mouse answers the need for ‘perfect thymectomies’. Secondly, the fact that the thymus involutes with ageing in normal individuals has of course suggested its involvement in the processes of senescence; and well-known theories attribute to it functions of immunological surveillance against ‘forbidden clones’ of aberrant lymphocytes. It therefore became natural that theathymic mouse should be used in the study of ageing. Lastly, the development of athymic foetuses and their survival, albeit with multiple abnormalities, raises questions--many of them newabout the roles and interactions of the thymus and other systems in the course of mammalian development. Analytical scrutiny of the functions of the thymus began in the 1940s, the main research tool being the experimentally t hymectomised laboratory mouse. A large amount of information has been obtained which has led to important generalisations concerning the immune response. These will not be discussed exhaustively, but will be summarised only, as a background to recent work with the ‘nude’ mouse. The latter is congenitally athymic, a fact which has already led, in the brief period since its discovery in 1968, to its wide use in immunology as well as in other fields related to mammalian differentiation and ageing. The investigations carried out in this field will be reviewed in some detail." @default.
- W2024100063 created "2016-06-24" @default.
- W2024100063 creator A5006047380 @default.
- W2024100063 date "1973-12-01" @default.
- W2024100063 modified "2023-10-17" @default.
- W2024100063 title "Athymic Development in the Mouse" @default.
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- W2024100063 doi "https://doi.org/10.1111/j.1432-0436.1973.tb00143.x" @default.
- W2024100063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4547146" @default.
- W2024100063 hasPublicationYear "1973" @default.