FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024264346> ?p ?o ?g. }

• W2024264346 endingPage "95" @default.
• W2024264346 startingPage "81" @default.
• W2024264346 abstract "The study of DNA damage at the chromosome level is an essential part of genetic toxicology because chromosomal mutation is an important event in carcinogenesis. The micronucleus assays have emerged as one of the preferred methods for assessing chromosome damage because they enable both chromosome loss and chromosome breakage to be measured reliably. Because micronuclei can only be expressed in cells that complete nuclear division a special method was developed that identifies such cells by their binucleate appearance when blocked from performing cytokinesis by cytochalasin-B (Cyt-B), a microfilament-assembly inhibitor. The cytokinesis-block micronucleus (CBMN) assay allows better precision because the data obtained are not confounded by altered cell division kinetics caused by cytotoxicity of agents tested or sub-optimal cell culture conditions. The method is now applied to various cell types for population monitoring of genetic damage, screening of chemicals for genotoxic potential and for specific purposes such as the prediction of the radiosensitivity of tumours and the inter-individual variation in radiosensitivity. In its current basic form the CBMN assay can provide, using simple morphological criteria, the following measures of genotoxicity and cytotoxicity: chromosome breakage, chromosome loss, chromosome rearrangement (nucleoplasmic bridges), cell division inhibition, necrosis and apoptosis. The cytosine-arabinoside modification of the CBMN assay allows for measurement of excision repairable lesions. The use of molecular probes enables chromosome loss to be distinguished from chromosome breakage and importantly non-disjunction in non-micronucleated binucleated cells can be efficiently measured. The in vitro CBMN technique, therefore, provides multiple and complementary measures of genotoxicity and cytotoxicity which can be achieved with relative ease within one system. The basic principles and methods (including detailed scoring criteria for all the genotoxicity and cytotoxicity end-points) of the CBMN assay are described and areas for future development identified." @default.
• W2024264346 created "2016-06-24" @default.
• W2024264346 creator A5007283353 @default.
• W2024264346 date "2000-11-01" @default.
• W2024264346 modified "2023-10-14" @default.
• W2024264346 title "The in vitro micronucleus technique" @default.
• W2024264346 cites W1974918432 @default.
• W2024264346 cites W1978813355 @default.
• W2024264346 cites W1979749238 @default.
• W2024264346 cites W1981772983 @default.
• W2024264346 cites W1983257624 @default.
• W2024264346 cites W1983415836 @default.
• W2024264346 cites W1988073250 @default.
• W2024264346 cites W1989579668 @default.
• W2024264346 cites W2002484337 @default.
• W2024264346 cites W2002798549 @default.
• W2024264346 cites W2004994748 @default.
• W2024264346 cites W2005815786 @default.
• W2024264346 cites W2010546442 @default.
• W2024264346 cites W2016277572 @default.
• W2024264346 cites W2016571415 @default.
• W2024264346 cites W2017674207 @default.
• W2024264346 cites W2018074319 @default.
• W2024264346 cites W2019777938 @default.
• W2024264346 cites W2035002706 @default.
• W2024264346 cites W2048467402 @default.
• W2024264346 cites W2048627720 @default.
• W2024264346 cites W2049155850 @default.
• W2024264346 cites W2052311965 @default.
• W2024264346 cites W2052594641 @default.
• W2024264346 cites W2053090235 @default.
• W2024264346 cites W2053500063 @default.
• W2024264346 cites W2056204961 @default.
• W2024264346 cites W2056262759 @default.
• W2024264346 cites W2067636124 @default.
• W2024264346 cites W2067800155 @default.
• W2024264346 cites W2071689676 @default.
• W2024264346 cites W2072477078 @default.
• W2024264346 cites W2076675939 @default.
• W2024264346 cites W2079635294 @default.
• W2024264346 cites W2082232487 @default.
• W2024264346 cites W2083770023 @default.
• W2024264346 cites W2086612545 @default.
• W2024264346 cites W2087400511 @default.
• W2024264346 cites W2088332066 @default.
• W2024264346 cites W2088682951 @default.
• W2024264346 cites W2094749173 @default.
• W2024264346 cites W2094895838 @default.
• W2024264346 cites W2098079466 @default.
• W2024264346 cites W2098883242 @default.
• W2024264346 cites W2102457163 @default.
• W2024264346 cites W2105623217 @default.
• W2024264346 cites W2112865167 @default.
• W2024264346 cites W2114771936 @default.
• W2024264346 cites W2123628489 @default.
• W2024264346 cites W2127279305 @default.
• W2024264346 cites W2140846028 @default.
• W2024264346 cites W2154771600 @default.
• W2024264346 cites W2157415501 @default.
• W2024264346 cites W2160131677 @default.
• W2024264346 cites W2163178796 @default.
• W2024264346 cites W2164898699 @default.
• W2024264346 cites W2326482175 @default.
• W2024264346 cites W2330695030 @default.
• W2024264346 cites W2896562410 @default.
• W2024264346 cites W4230974614 @default.
• W2024264346 cites W4379373823 @default.
• W2024264346 doi "https://doi.org/10.1016/s0027-5107(00)00065-8" @default.
• W2024264346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11113469" @default.
• W2024264346 hasPublicationYear "2000" @default.
• W2024264346 type Work @default.
• W2024264346 sameAs 2024264346 @default.
• W2024264346 citedByCount "2137" @default.
• W2024264346 countsByYear W20242643462012 @default.
• W2024264346 countsByYear W20242643462013 @default.
• W2024264346 countsByYear W20242643462014 @default.
• W2024264346 countsByYear W20242643462015 @default.
• W2024264346 countsByYear W20242643462016 @default.
• W2024264346 countsByYear W20242643462017 @default.
• W2024264346 countsByYear W20242643462018 @default.
• W2024264346 countsByYear W20242643462019 @default.
• W2024264346 countsByYear W20242643462020 @default.
• W2024264346 countsByYear W20242643462021 @default.
• W2024264346 countsByYear W20242643462022 @default.
• W2024264346 countsByYear W20242643462023 @default.
• W2024264346 crossrefType "journal-article" @default.
• W2024264346 hasAuthorship W2024264346A5007283353 @default.
• W2024264346 hasConcept C104317684 @default.
• W2024264346 hasConcept C144024400 @default.
• W2024264346 hasConcept C149923435 @default.
• W2024264346 hasConcept C153911025 @default.
• W2024264346 hasConcept C178790620 @default.
• W2024264346 hasConcept C185592680 @default.
• W2024264346 hasConcept C2778959862 @default.
• W2024264346 hasConcept C2908647359 @default.
• W2024264346 hasConcept C29730261 @default.
• W2024264346 hasConcept C30481170 @default.
• W2024264346 hasConcept C36681516 @default.

• next