FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024409898> ?p ?o ?g. }

• W2024409898 endingPage "971" @default.
• W2024409898 startingPage "963" @default.
• W2024409898 abstract "Objective: To investigate whether systemic erythropoietin administration can prevent secondary burn progression in an experimental model and to elucidate the underlying mechanisms. Design: Prospective study. Setting: University-based laboratory research. Subjects: Twenty-one male Wistar rats. Interventions: The burn comb model creates four rectangular burned surfaces that are intercalated by three unburned zones (interspaces) prone to secondary necrosis. Twenty-one animals were randomized to three experimental groups: 1) Local cooling with water for 20 minutes (control, 17°C); 2) and 3) local cooling with water and intraperitoneal erythropoietin once a day for five days starting 45 minutes after burn injury (500 IU/kg body weight: EPO 500 or 2500 IU/kg body weight: EPO 2500). Measurements and Main Results: Secondary burn progression—both in depth (histology) and in surface (planimetry)—as well as interspace perfusion (laser Doppler flowmetry) and hematocrit were analyzed. Further, dilatory response (inducible nitric oxide synthase expression), inflammation (leukocyte count), and angiogenesis (CD31 expression) were assessed. Finally, wound healing time and contracture rate were reported. Burn progression resulted in complete dermal destruction as well as in important interspace necrosis in control animals, whereas burn progression was significantly reduced in a dose-dependent manner in animals treated with erythropoietin. Tissue protection was associated with an increased interspace perfusion with EPO 500, but not with EPO 2500, and was paralleled by a significant increase in inducible nitric oxide synthase expression and decreased inflammation, independent of the erythropoietin dosage. EPO 2500 led to a significant increase of hematocrit at day 4. Finally, faster wound healing and less contracture were observed in animals treated with EPO 500 only. Conclusions: Erythropoietin represents an easy-to-use therapeutic approach to prevent secondary burn progression, i.e., to control damage after burn injury. It preserves microcirculatory perfusion within the endangered areas in a dose-dependent manner." @default.
• W2024409898 created "2016-06-24" @default.
• W2024409898 creator A5013126553 @default.
• W2024409898 creator A5023802424 @default.
• W2024409898 creator A5032711637 @default.
• W2024409898 creator A5046366642 @default.
• W2024409898 date "2013-04-01" @default.
• W2024409898 modified "2023-10-16" @default.
• W2024409898 title "Secondary Burn Progression Decreased by Erythropoietin*" @default.
• W2024409898 cites W189180901 @default.
• W2024409898 cites W1975485605 @default.
• W2024409898 cites W1979856207 @default.
• W2024409898 cites W1980407464 @default.
• W2024409898 cites W1981510077 @default.
• W2024409898 cites W1983588728 @default.
• W2024409898 cites W2015025950 @default.
• W2024409898 cites W2028360273 @default.
• W2024409898 cites W2030409041 @default.
• W2024409898 cites W2039211509 @default.
• W2024409898 cites W2043122186 @default.
• W2024409898 cites W2045677954 @default.
• W2024409898 cites W2054288121 @default.
• W2024409898 cites W2056522441 @default.
• W2024409898 cites W2058141781 @default.
• W2024409898 cites W2073429818 @default.
• W2024409898 cites W2074713615 @default.
• W2024409898 cites W2075901022 @default.
• W2024409898 cites W2086870884 @default.
• W2024409898 cites W2101059163 @default.
• W2024409898 cites W2116400576 @default.
• W2024409898 cites W2126752581 @default.
• W2024409898 cites W2132498904 @default.
• W2024409898 cites W2157312122 @default.
• W2024409898 cites W2159479773 @default.
• W2024409898 cites W2159916913 @default.
• W2024409898 cites W2162264368 @default.
• W2024409898 cites W2168414115 @default.
• W2024409898 doi "https://doi.org/10.1097/ccm.0b013e318275cee7" @default.
• W2024409898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23324953" @default.
• W2024409898 hasPublicationYear "2013" @default.
• W2024409898 type Work @default.
• W2024409898 sameAs 2024409898 @default.
• W2024409898 citedByCount "30" @default.
• W2024409898 countsByYear W20244098982013 @default.
• W2024409898 countsByYear W20244098982014 @default.
• W2024409898 countsByYear W20244098982015 @default.
• W2024409898 countsByYear W20244098982016 @default.
• W2024409898 countsByYear W20244098982017 @default.
• W2024409898 countsByYear W20244098982018 @default.
• W2024409898 countsByYear W20244098982019 @default.
• W2024409898 countsByYear W20244098982020 @default.
• W2024409898 countsByYear W20244098982021 @default.
• W2024409898 countsByYear W20244098982022 @default.
• W2024409898 countsByYear W20244098982023 @default.
• W2024409898 crossrefType "journal-article" @default.
• W2024409898 hasAuthorship W2024409898A5013126553 @default.
• W2024409898 hasAuthorship W2024409898A5023802424 @default.
• W2024409898 hasAuthorship W2024409898A5032711637 @default.
• W2024409898 hasAuthorship W2024409898A5046366642 @default.
• W2024409898 hasConcept C126322002 @default.
• W2024409898 hasConcept C126894567 @default.
• W2024409898 hasConcept C141071460 @default.
• W2024409898 hasConcept C142724271 @default.
• W2024409898 hasConcept C146957229 @default.
• W2024409898 hasConcept C2776914184 @default.
• W2024409898 hasConcept C2778534260 @default.
• W2024409898 hasConcept C2780959883 @default.
• W2024409898 hasConcept C2993242423 @default.
• W2024409898 hasConcept C503630168 @default.
• W2024409898 hasConcept C71924100 @default.
• W2024409898 hasConceptScore W2024409898C126322002 @default.
• W2024409898 hasConceptScore W2024409898C126894567 @default.
• W2024409898 hasConceptScore W2024409898C141071460 @default.
• W2024409898 hasConceptScore W2024409898C142724271 @default.
• W2024409898 hasConceptScore W2024409898C146957229 @default.
• W2024409898 hasConceptScore W2024409898C2776914184 @default.
• W2024409898 hasConceptScore W2024409898C2778534260 @default.
• W2024409898 hasConceptScore W2024409898C2780959883 @default.
• W2024409898 hasConceptScore W2024409898C2993242423 @default.
• W2024409898 hasConceptScore W2024409898C503630168 @default.
• W2024409898 hasConceptScore W2024409898C71924100 @default.
• W2024409898 hasIssue "4" @default.
• W2024409898 hasLocation W20244098981 @default.
• W2024409898 hasLocation W20244098982 @default.
• W2024409898 hasOpenAccess W2024409898 @default.
• W2024409898 hasPrimaryLocation W20244098981 @default.
• W2024409898 hasRelatedWork W1519526289 @default.
• W2024409898 hasRelatedWork W1552381745 @default.
• W2024409898 hasRelatedWork W1588725841 @default.
• W2024409898 hasRelatedWork W1592859225 @default.
• W2024409898 hasRelatedWork W1602405375 @default.
• W2024409898 hasRelatedWork W2051884508 @default.
• W2024409898 hasRelatedWork W2085281796 @default.
• W2024409898 hasRelatedWork W2179797810 @default.
• W2024409898 hasRelatedWork W2415995798 @default.
• W2024409898 hasRelatedWork W4256664370 @default.
• W2024409898 hasVolume "41" @default.
• W2024409898 isParatext "false" @default.

• next