FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025390110> ?p ?o ?g. }

• W2025390110 endingPage "305" @default.
• W2025390110 startingPage "305" @default.
• W2025390110 abstract "Synergism from the combination of ulinastatin and curcumin offers greater inhibition against colorectal cancer liver metastases via modulating matrix metalloproteinase-9 and E-cadherin expression Fei Shen,1 Wen-Song Cai,1 Jiang-Lin Li,1 Zhe Feng,1 Qi-cai Liu,2 Huan-qing Xiao,1 Jie Cao,1 Bo Xu1 1Department of General Surgery, Guangzhou First People&#39;s Hospital, Guangzhou Medical University, Guangzhou, People&#39;s Republic of China; 2Experimental Medical Research Center, Guangzhou Medical University, Guangzhou, People&#39;s Republic of China Abstract: Liver metastasis is a major cause of mortality in colorectal cancer (CRC). The current study was to investigate the ability of ulinastatin (UTI) and curcumin (CUR) to inhibit CRC liver metastases via modulating matrix metalloproteinase-9 (MMP-9) and E-cadherin expression. Human CRC HCT-116 cells were treated with compounds individually and in combination in order to understand the effect on cell migration and invasion. The HCT-116 cell line was established to stably express luciferase and green fluorescent protein (GFP) by lentiviral transduction (HCT-116-Luc-GFP). We identified an anti-metastasis effect of UTI and CUR on a CRC liver metastasis mouse model. Tumor development and therapeutic responses were dynamically tracked by bioluminescence imaging. Expression of MMP-9 and E-cadherin in metastatic tumors was detected by immunohistochemical assay. Results of wound healing and cell invasion assays suggest that treatment with UTI, CUR, and UTI plus CUR, respectively, significantly inhibit HCT-116 cell migration and invasion. Furthermore, results of CRC hepatic metastasis on a nude mouse model showed that treatment with UTI, CUR alone, and a combination notably inhibited hepatic metastases from CRC and prolonged survival of tumor-bearing mice, especially in the UTI plus CUR group. These results suggest that the combination of UTI and CUR together may offer greater inhibition against metastasis of CRC. Keywords: hepatic metastasis, bioluminescence imaging, therapy" @default.
• W2025390110 created "2016-06-24" @default.
• W2025390110 creator A5002533329 @default.
• W2025390110 creator A5016374699 @default.
• W2025390110 creator A5033299323 @default.
• W2025390110 creator A5042824297 @default.
• W2025390110 creator A5047546722 @default.
• W2025390110 creator A5055828140 @default.
• W2025390110 creator A5073406775 @default.
• W2025390110 creator A5079711212 @default.
• W2025390110 date "2014-02-01" @default.
• W2025390110 modified "2023-10-18" @default.
• W2025390110 title "Synergism from the combination of ulinastatin and curcumin offers greater inhibition against colorectal cancer liver metastases via modulating matrix metalloproteinase-9 and E-cadherin expression" @default.
• W2025390110 cites W1977268172 @default.
• W2025390110 cites W1982275767 @default.
• W2025390110 cites W1982397837 @default.
• W2025390110 cites W1983082314 @default.
• W2025390110 cites W2000978979 @default.
• W2025390110 cites W2019949382 @default.
• W2025390110 cites W2036516235 @default.
• W2025390110 cites W2040438865 @default.
• W2025390110 cites W2042965279 @default.
• W2025390110 cites W2044896610 @default.
• W2025390110 cites W2051247936 @default.
• W2025390110 cites W2051845827 @default.
• W2025390110 cites W2055869319 @default.
• W2025390110 cites W2061153713 @default.
• W2025390110 cites W2062570896 @default.
• W2025390110 cites W2065120229 @default.
• W2025390110 cites W2070204856 @default.
• W2025390110 cites W2078686061 @default.
• W2025390110 cites W2081577203 @default.
• W2025390110 cites W2088114240 @default.
• W2025390110 cites W2106243023 @default.
• W2025390110 cites W2106787323 @default.
• W2025390110 cites W2108101344 @default.
• W2025390110 cites W2109277581 @default.
• W2025390110 cites W2113844929 @default.
• W2025390110 cites W2123378132 @default.
• W2025390110 cites W2130960022 @default.
• W2025390110 cites W2147152447 @default.
• W2025390110 cites W2170237516 @default.
• W2025390110 cites W2409383369 @default.
• W2025390110 doi "https://doi.org/10.2147/ott.s57126" @default.
• W2025390110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3933719" @default.
• W2025390110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24570592" @default.
• W2025390110 hasPublicationYear "2014" @default.
• W2025390110 type Work @default.
• W2025390110 sameAs 2025390110 @default.
• W2025390110 citedByCount "12" @default.
• W2025390110 countsByYear W20253901102015 @default.
• W2025390110 countsByYear W20253901102017 @default.
• W2025390110 countsByYear W20253901102018 @default.
• W2025390110 countsByYear W20253901102019 @default.
• W2025390110 countsByYear W20253901102020 @default.
• W2025390110 countsByYear W20253901102021 @default.
• W2025390110 crossrefType "journal-article" @default.
• W2025390110 hasAuthorship W2025390110A5002533329 @default.
• W2025390110 hasAuthorship W2025390110A5016374699 @default.
• W2025390110 hasAuthorship W2025390110A5033299323 @default.
• W2025390110 hasAuthorship W2025390110A5042824297 @default.
• W2025390110 hasAuthorship W2025390110A5047546722 @default.
• W2025390110 hasAuthorship W2025390110A5055828140 @default.
• W2025390110 hasAuthorship W2025390110A5073406775 @default.
• W2025390110 hasAuthorship W2025390110A5079711212 @default.
• W2025390110 hasBestOaLocation W20253901101 @default.
• W2025390110 hasConcept C109523444 @default.
• W2025390110 hasConcept C121608353 @default.
• W2025390110 hasConcept C126322002 @default.
• W2025390110 hasConcept C142724271 @default.
• W2025390110 hasConcept C147447768 @default.
• W2025390110 hasConcept C1491633281 @default.
• W2025390110 hasConcept C149402561 @default.
• W2025390110 hasConcept C204232928 @default.
• W2025390110 hasConcept C2778250585 @default.
• W2025390110 hasConcept C2779013556 @default.
• W2025390110 hasConcept C2781246285 @default.
• W2025390110 hasConcept C502942594 @default.
• W2025390110 hasConcept C526805850 @default.
• W2025390110 hasConcept C54355233 @default.
• W2025390110 hasConcept C71924100 @default.
• W2025390110 hasConcept C86803240 @default.
• W2025390110 hasConcept C98274493 @default.
• W2025390110 hasConceptScore W2025390110C109523444 @default.
• W2025390110 hasConceptScore W2025390110C121608353 @default.
• W2025390110 hasConceptScore W2025390110C126322002 @default.
• W2025390110 hasConceptScore W2025390110C142724271 @default.
• W2025390110 hasConceptScore W2025390110C147447768 @default.
• W2025390110 hasConceptScore W2025390110C1491633281 @default.
• W2025390110 hasConceptScore W2025390110C149402561 @default.
• W2025390110 hasConceptScore W2025390110C204232928 @default.
• W2025390110 hasConceptScore W2025390110C2778250585 @default.
• W2025390110 hasConceptScore W2025390110C2779013556 @default.
• W2025390110 hasConceptScore W2025390110C2781246285 @default.
• W2025390110 hasConceptScore W2025390110C502942594 @default.
• W2025390110 hasConceptScore W2025390110C526805850 @default.
• W2025390110 hasConceptScore W2025390110C54355233 @default.
• W2025390110 hasConceptScore W2025390110C71924100 @default.

• next