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• W2025788045 startingPage "101" @default.
• W2025788045 abstract "The goal of this exploratory pilot study was to use gamma scintigraphy to evaluate, under physiological conditions, disintegration profiles of encapsulated and nonencapsulated formulations of 100 mg sumatriptan. Using a crossover design, healthy volunteers (n = 10) ingested 100-mg doses of sumatriptan tablets radiolabeled with 111Indium, as well as encapsulated sumatriptan tablets that were prepared similarly, then placed within a gelatin capsule and backfilled with an excipient blend radiolabeled with 99mTechnetium. A gamma camera recorded scintigraphic images until 5 hours postdose. Initial disintegration of the gelatin capsule was observed at a mean (range) of 5 minutes (1–11 minutes); disintegration was complete within 14 minutes (5–24 minutes). For nonencapsulated versus encapsulated tablets, the mean (± standard deviation) time to initial disintegration (6 ± 5 minutes vs 8 ± 5 minutes) and time to complete disintegration (18 ± 14 minutes vs 16 ± 7 minutes) were comparable. Results of this study demonstrate that encapsulated and nonencapsulated sumatriptan have equivalent in vivo dissolution rates." @default.
• W2025788045 created "2016-06-24" @default.
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• W2025788045 date "2005-01-01" @default.
• W2025788045 modified "2023-09-26" @default.
• W2025788045 title "In Vivo Disintegration Profiles of Encapsulated and Nonencapsulated Sumatriptan: Gamma Scintigraphy in Healthy Volunteers" @default.
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• W2025788045 doi "https://doi.org/10.1177/0091270004270560" @default.
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