FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025890371> ?p ?o ?g. }

• W2025890371 endingPage "11" @default.
• W2025890371 startingPage "1" @default.
• W2025890371 abstract "Virus entry is a multistep process that triggers various cellular pathways that interconnect into a complex network; yet the molecular complexity of this network remains largely elusive. Here, by employing systems biology approaches, we reveal a systemic virus-entry network initiated by human cytomegalovirus (HCMV), a widespread opportunistic pathogen. This network contains ten functional modules (i.e., groups of proteins) that coordinately respond to HCMV entry. Functional modules activated (up- and downregulated) in this network dramatically decline shortly within 25 minutes post infection. While modules annotated as receptor system, ion transport, and immune response are continuously activated during the entire process of HCMV entry, those annotated for cell adhesion and skeletal movement are specifically activated during viral early attachment. The up-regulated network contains various functional modules, such as cell surface receptors, skeletal development, endocytosis, ion transport, and chromatin remodeling. Interestingly, macromolecule metabolism and chromatin remodeling module predominates this over-expressed system, suggesting that the fundamental nuclear process modulation is one of the most important events in HCMV entry. The entire up-regulated network is primarily controlled by multiple elements like SLC10A1. Thus, virus entry triggers multiple cellular processes especially nuclear processes to facilitate its entry." @default.
• W2025890371 created "2016-06-24" @default.
• W2025890371 creator A5027024205 @default.
• W2025890371 creator A5037507969 @default.
• W2025890371 creator A5088419681 @default.
• W2025890371 date "2011-01-01" @default.
• W2025890371 modified "2023-09-26" @default.
• W2025890371 title "A Systemic Network Triggered by Human Cytomegalovirus Entry" @default.
• W2025890371 cites W125742586 @default.
• W2025890371 cites W1503791187 @default.
• W2025890371 cites W1525985997 @default.
• W2025890371 cites W1587602994 @default.
• W2025890371 cites W1847639248 @default.
• W2025890371 cites W1950736399 @default.
• W2025890371 cites W1965202893 @default.
• W2025890371 cites W1970350442 @default.
• W2025890371 cites W1976489150 @default.
• W2025890371 cites W1991662448 @default.
• W2025890371 cites W1992951628 @default.
• W2025890371 cites W1995744610 @default.
• W2025890371 cites W1995826732 @default.
• W2025890371 cites W1996688582 @default.
• W2025890371 cites W1997050095 @default.
• W2025890371 cites W2005017965 @default.
• W2025890371 cites W2007134676 @default.
• W2025890371 cites W2008116181 @default.
• W2025890371 cites W2009412756 @default.
• W2025890371 cites W2020284906 @default.
• W2025890371 cites W2030214324 @default.
• W2025890371 cites W2038495337 @default.
• W2025890371 cites W2040101892 @default.
• W2025890371 cites W2040379229 @default.
• W2025890371 cites W2054165784 @default.
• W2025890371 cites W2061589432 @default.
• W2025890371 cites W2065197515 @default.
• W2025890371 cites W2068385982 @default.
• W2025890371 cites W2069800788 @default.
• W2025890371 cites W2079377885 @default.
• W2025890371 cites W2101181377 @default.
• W2025890371 cites W2104124112 @default.
• W2025890371 cites W2106968157 @default.
• W2025890371 cites W2107655439 @default.
• W2025890371 cites W2123500593 @default.
• W2025890371 cites W2132992030 @default.
• W2025890371 cites W2134672568 @default.
• W2025890371 cites W2138623102 @default.
• W2025890371 cites W2147714160 @default.
• W2025890371 cites W2150318080 @default.
• W2025890371 cites W2152653671 @default.
• W2025890371 cites W2154947819 @default.
• W2025890371 cites W2160697532 @default.
• W2025890371 cites W2163480486 @default.
• W2025890371 cites W2166311080 @default.
• W2025890371 cites W2171030481 @default.
• W2025890371 doi "https://doi.org/10.1155/2011/262080" @default.
• W2025890371 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3263853" @default.
• W2025890371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22312338" @default.
• W2025890371 hasPublicationYear "2011" @default.
• W2025890371 type Work @default.
• W2025890371 sameAs 2025890371 @default.
• W2025890371 citedByCount "6" @default.
• W2025890371 countsByYear W20258903712012 @default.
• W2025890371 countsByYear W20258903712013 @default.
• W2025890371 countsByYear W20258903712016 @default.
• W2025890371 countsByYear W20258903712017 @default.
• W2025890371 crossrefType "journal-article" @default.
• W2025890371 hasAuthorship W2025890371A5027024205 @default.
• W2025890371 hasAuthorship W2025890371A5037507969 @default.
• W2025890371 hasAuthorship W2025890371A5088419681 @default.
• W2025890371 hasBestOaLocation W20258903711 @default.
• W2025890371 hasConcept C140704245 @default.
• W2025890371 hasConcept C170493617 @default.
• W2025890371 hasConcept C203014093 @default.
• W2025890371 hasConcept C2522874641 @default.
• W2025890371 hasConcept C2779820661 @default.
• W2025890371 hasConcept C28005876 @default.
• W2025890371 hasConcept C54355233 @default.
• W2025890371 hasConcept C58475186 @default.
• W2025890371 hasConcept C86803240 @default.
• W2025890371 hasConcept C95444343 @default.
• W2025890371 hasConceptScore W2025890371C140704245 @default.
• W2025890371 hasConceptScore W2025890371C170493617 @default.
• W2025890371 hasConceptScore W2025890371C203014093 @default.
• W2025890371 hasConceptScore W2025890371C2522874641 @default.
• W2025890371 hasConceptScore W2025890371C2779820661 @default.
• W2025890371 hasConceptScore W2025890371C28005876 @default.
• W2025890371 hasConceptScore W2025890371C54355233 @default.
• W2025890371 hasConceptScore W2025890371C58475186 @default.
• W2025890371 hasConceptScore W2025890371C86803240 @default.
• W2025890371 hasConceptScore W2025890371C95444343 @default.
• W2025890371 hasLocation W20258903711 @default.
• W2025890371 hasLocation W20258903712 @default.
• W2025890371 hasLocation W20258903713 @default.
• W2025890371 hasLocation W20258903714 @default.
• W2025890371 hasLocation W20258903715 @default.
• W2025890371 hasOpenAccess W2025890371 @default.
• W2025890371 hasPrimaryLocation W20258903711 @default.
• W2025890371 hasRelatedWork W1484542705 @default.

• next