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• W2026550718 abstract "Argonaute (Ago) proteins are the effector proteins of RNA interference (RNAi) and related silencing mechanisms that are mediated by small RNAs. Ago proteins bind directly to microRNAs (miRNAs) and to short interfering RNAs and are the core protein components of RNA induced silencing complexes (RISCs) and microRNPs (miRNPs). Here we report that an ~70-nt RNA associates specifically with immunopurified Ago2 expressed in human 293 cells. By directional cloning we identified this RNA as the mitochondrial tRNA(Met) (mt tRNA(Met)). Various exported (mt) tRNAs were detected in the cytosol of 293 cells, but Ago2 was found selectively bound to (mt) tRNA(Met). The association in the cytosol of exported (mt) tRNA(Met) with Ago2 complements genetic and microscopic data that link mitochondria with RNAi-related components and events." @default.
• W2026550718 created "2016-06-24" @default.
• W2026550718 creator A5046236334 @default.
• W2026550718 creator A5074999929 @default.
• W2026550718 date "2005-05-04" @default.
• W2026550718 modified "2023-09-29" @default.
• W2026550718 title "Human mitochondrial tRNA^Met is exported to the cytoplasm and associates with the Argonaute 2 protein" @default.
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• W2026550718 doi "https://doi.org/10.1261/rna.2210805" @default.
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