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• W2027016772 abstract "CXCL12, also known as stromal cell-derived factor (SDF-1), is a CXC chemokine. Recent reports have shown that CXCL12 might play key roles in a murine model of lupus and in patients with systemic lupus erythematosus (SLE). A common variant at position 801 in 3′-untranslated region in CXCL12 gene (designated CXCL12-3′G801A) has been reported in association with autoimmune diseases, such as type 1 diabetes and systemic sclerosis. We investigated the influence of CXCL12-3′G801A polymorphism on susceptibility to SLE by genotyping this single nucleotide polymorphism in 422 SLE patients and 374 healthy controls. The frequency of G/G homozygote was observed in 60.0% of SLE patients and in 52.7% of healthy individuals (χ 2 = 4.275, p = 0.039). Compared with patients with G/A and A/A genotype, SLE patients with G/G genotype were also more prone to developing photosensitivity (χ 2 = 6.778, p = 0.034), renal damage (χ 2 = 6.388, p = 0.041) and to producing antibodies against nucleosomes (χ 2 = 8.341, p = 0.015). Moreover, the plasma level of CXCL12α was also significantly increased in patients with G/G homozygote than in healthy controls carrying the same genotype [(4067.0 ± 1092.3) pg/ml vs. (3278.5 ± 547.4) pg/ml, p = 0.002]. Our results suggest that polymorphism in CXCL12-3′G801A might be a genetic risk factor for developing SLE. The association of G/G homozygote with nephritis and skin damage developed in SLE patients might be due to its effects upon the production of auto-antibodies and CXCL12 protein." @default.
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• W2027016772 date "2012-02-06" @default.
• W2027016772 modified "2023-09-26" @default.
• W2027016772 title "Association of chemokine CXCL12-3′G801A polymorphism with systemic lupus erythematosus in a Han Chinese population" @default.
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• W2027016772 doi "https://doi.org/10.1177/0961203311435266" @default.
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