Matches in SemOpenAlex for { <https://semopenalex.org/work/W2027441036> ?p ?o ?g. }
- W2027441036 endingPage "1161" @default.
- W2027441036 startingPage "1161" @default.
- W2027441036 abstract "Evaluating the safety and efficacy of dextromethorphan/quinidine in the treatment of pseudobulbar affect Kerri A Schoedel,1 Sarah A Morrow,2 Edward M Sellers3,4 1Altreos Research Partners, Inc., Toronto, 2Western University, London, 3DL Global Partners, Inc., Toronto, 4University of Toronto, Toronto, Ontario, Canada Abstract: Pseudobulbar affect (PBA) is a common manifestation of brain pathology associated with many neurological diseases, including amyotrophic lateral sclerosis, Alzheimer’s disease, stroke, multiple sclerosis, Parkinson’s disease, and traumatic brain injury. PBA is defined by involuntary and uncontrollable expressed emotion that is exaggerated and inappropriate, and also incongruent with the underlying emotional state. Dextromethorphan/quinidine (DM/Q) is a combination product indicated for the treatment of PBA. The quinidine component of DM/Q inhibits the cytochrome P450 2D6-mediated metabolic conversion of dextromethorphan to its active metabolite dextrorphan, thereby increasing dextromethorphan systemic bioavailability and driving the pharmacology toward that of the parent drug and away from adverse effects of the dextrorphan metabolite. Three published efficacy and safety studies support the use of DM/Q in the treatment of PBA; significant effects were seen on the primary end point, the Center for Neurologic Study-Lability Scale, as well as secondary efficacy end points and quality of life. While concentration–effect relationships appear relatively weak for efficacy parameters, concentrations of DM/Q may have an impact on safety. Some special safety concerns exist with DM/Q, primarily because of the drug interaction and QT prolongation potential of the quinidine component. However, because concentrations of dextrorphan (which is responsible for many of the parent drug’s side effects) and quinidine are lower than those observed in clinical practice with these drugs administered alone, some of the perceived safety issues may not be as relevant with this low dose combination product. However, since patients with PBA have a variety of other medical problems and are on numerous other medications, they may not tolerate DM/Q adverse effects, or may be at risk for drug interactions. Some caution is warranted when initiating DM/Q treatment, particularly in patients with underlying risk factors for torsade de pointes and in those receiving medications that may interact with DM/Q. Keywords: clinical pharmacology, Nuedexta, drug interactions, CYP2D6, QTc interval, CNS-LS" @default.
- W2027441036 created "2016-06-24" @default.
- W2027441036 creator A5002986623 @default.
- W2027441036 creator A5013791504 @default.
- W2027441036 creator A5037427363 @default.
- W2027441036 date "2014-06-01" @default.
- W2027441036 modified "2023-10-18" @default.
- W2027441036 title "Evaluating the safety and efficacy of dextromethorphan/quinidine in the treatment of pseudobulbar affect" @default.
- W2027441036 cites W1471099170 @default.
- W2027441036 cites W1491928898 @default.
- W2027441036 cites W1510400828 @default.
- W2027441036 cites W1559218836 @default.
- W2027441036 cites W1564667278 @default.
- W2027441036 cites W1568078031 @default.
- W2027441036 cites W1883612618 @default.
- W2027441036 cites W1942711492 @default.
- W2027441036 cites W1955305547 @default.
- W2027441036 cites W1957078918 @default.
- W2027441036 cites W1965228291 @default.
- W2027441036 cites W1965432721 @default.
- W2027441036 cites W1965541116 @default.
- W2027441036 cites W1967255964 @default.
- W2027441036 cites W1969864513 @default.
- W2027441036 cites W1972199968 @default.
- W2027441036 cites W1973343474 @default.
- W2027441036 cites W1973458981 @default.
- W2027441036 cites W1977091534 @default.
- W2027441036 cites W1981709770 @default.
- W2027441036 cites W1982123478 @default.
- W2027441036 cites W1984850614 @default.
- W2027441036 cites W1986443718 @default.
- W2027441036 cites W1989438200 @default.
- W2027441036 cites W1993492984 @default.
- W2027441036 cites W1994316896 @default.
- W2027441036 cites W1994492347 @default.
- W2027441036 cites W1996649698 @default.
- W2027441036 cites W1999964617 @default.
- W2027441036 cites W2000782600 @default.
- W2027441036 cites W2003909914 @default.
- W2027441036 cites W2003966019 @default.
- W2027441036 cites W2006625958 @default.
- W2027441036 cites W2013235742 @default.
- W2027441036 cites W2013266770 @default.
- W2027441036 cites W2016311788 @default.
- W2027441036 cites W2016911934 @default.
- W2027441036 cites W2018608742 @default.
- W2027441036 cites W2018930912 @default.
- W2027441036 cites W2019812486 @default.
- W2027441036 cites W2021166705 @default.
- W2027441036 cites W2021814611 @default.
- W2027441036 cites W2021928801 @default.
- W2027441036 cites W2023824310 @default.
- W2027441036 cites W2027731572 @default.
- W2027441036 cites W2027987251 @default.
- W2027441036 cites W2030005246 @default.
- W2027441036 cites W2031176987 @default.
- W2027441036 cites W2032238499 @default.
- W2027441036 cites W2033461129 @default.
- W2027441036 cites W2038673720 @default.
- W2027441036 cites W2039867887 @default.
- W2027441036 cites W2041263535 @default.
- W2027441036 cites W2042677358 @default.
- W2027441036 cites W2043221233 @default.
- W2027441036 cites W2046558323 @default.
- W2027441036 cites W2047301834 @default.
- W2027441036 cites W2048514608 @default.
- W2027441036 cites W2051758404 @default.
- W2027441036 cites W2052629510 @default.
- W2027441036 cites W2052694988 @default.
- W2027441036 cites W2055605433 @default.
- W2027441036 cites W2055936731 @default.
- W2027441036 cites W2056091708 @default.
- W2027441036 cites W2056969868 @default.
- W2027441036 cites W2059248961 @default.
- W2027441036 cites W2060695182 @default.
- W2027441036 cites W2063599025 @default.
- W2027441036 cites W2064711426 @default.
- W2027441036 cites W2070663758 @default.
- W2027441036 cites W2073494396 @default.
- W2027441036 cites W2075436847 @default.
- W2027441036 cites W2075851302 @default.
- W2027441036 cites W2077965891 @default.
- W2027441036 cites W2081517567 @default.
- W2027441036 cites W2084551554 @default.
- W2027441036 cites W2086204057 @default.
- W2027441036 cites W2086222128 @default.
- W2027441036 cites W2092829315 @default.
- W2027441036 cites W2095301214 @default.
- W2027441036 cites W2096731409 @default.
- W2027441036 cites W2102268427 @default.
- W2027441036 cites W2108568993 @default.
- W2027441036 cites W2111879726 @default.
- W2027441036 cites W2113927644 @default.
- W2027441036 cites W2115598792 @default.
- W2027441036 cites W2120130609 @default.
- W2027441036 cites W2120146331 @default.
- W2027441036 cites W2120845763 @default.
- W2027441036 cites W2123608858 @default.