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- W2027720504 abstract "Here we investigated the neuroprotective effect of resveratrol in an in vitro model of ischemia. We used organotypic hippocampal cultures exposed to oxygen–glucose deprivation (OGD). In OGD-vehicle exposed cultures, about 46% of the hippocampus was labeled with PI, indicating a robust percentage of cell death. When cultures were treated with resveratrol 10, 25 and 50 μM, the cell death was reduced to 22, 20 and 13% respectively. To elucidate a possible mechanism by which resveratrol exerts its neuroprotective effect, we investigated the phosphoinositide3-kinase (PI3-k) pathway using LY294002 (5 μM) and mitogen-activated protein kinase (MAPK) using PD98059 (20 μM). The resveratrol (50 μM) neuroprotection was prevented by LY294002 but was not by PD98059. Immunoblotting revealed that resveratrol 50 μM induced the phosphorylation/activation of Akt and extracellular signal-regulated kinase-1 and -2 (ERK1/2) and the phosphorylation/inactivation of glycogen synthase kinase-3β (GSK-3β).Our results suggest that PI3-k/Akt pathway are involved in the neuroprotective effect of resveratrol." @default.
- W2027720504 created "2016-06-24" @default.
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- W2027720504 date "2006-10-01" @default.
- W2027720504 modified "2023-10-15" @default.
- W2027720504 title "Protective effect of resveratrol against oxygen–glucose deprivation in organotypic hippocampal slice cultures: Involvement of PI3-K pathway" @default.
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- W2027720504 cites W1529774113 @default.
- W2027720504 cites W1536483289 @default.
- W2027720504 cites W1539503465 @default.
- W2027720504 cites W1540436551 @default.
- W2027720504 cites W154564172 @default.
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- W2027720504 cites W1573664132 @default.
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- W2027720504 cites W1907196977 @default.
- W2027720504 cites W1971915141 @default.
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- W2027720504 cites W1978062354 @default.
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- W2027720504 cites W1986327387 @default.
- W2027720504 cites W1989086320 @default.
- W2027720504 cites W1989969820 @default.
- W2027720504 cites W1991148019 @default.
- W2027720504 cites W1996886208 @default.
- W2027720504 cites W2012778582 @default.
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- W2027720504 doi "https://doi.org/10.1016/j.nbd.2006.06.002" @default.
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