FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029528089> ?p ?o ?g. }

• W2029528089 endingPage "147" @default.
• W2029528089 startingPage "138" @default.
• W2029528089 abstract "Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are formed from the oxidative metabolism of polybrominated diphenyl ethers (PBDEs) in humans, rats and mice, but their quantitation in human blood and other matrices with liquid chromatography–mass spectrometric techniques has been a challenge. In this study, a novel analytical method was developed and validated using only 250 μL of human serum for the quantitation of twelve OH-PBDEs, fully chromatographically separated in a 15 min analytical run. This method includes two novel approaches: an enzymatic hydrolysis procedure and a chromatographic separation using a mixed mode chromatography column. The enzymatic hydrolysis (EH) was found critical for 4′-OH-BDE17, which was not detectable without it. For the sample clean up, a solid phase extraction protocol was developed and validated for the extraction of the 12 congeners from human serum. In addition, for the first time baseline resolution of two components was achieved that correspond to a single peak previously identified as 6′-OH-BDE99. The method was validated for linearity, accuracy, precision, matrix effects, limit of quantification, limit of detection, sample stability and overall efficiency. Recoveries (absolute and relative) ranged from 66 to 130% with relative standard deviations <21% for all analytes. Limit of detection and quantitation ranged from 4 to 90 pg mL−1 and 6–120 pg mL−1, respectively, with no carry over effects. This method was applied in ten commercially available human serum samples from the general US population. The mean values of the congeners detected in all samples are 4′-OH-BDE17 (34.2 pg mL−1), 4-OH-BDE42 (33.9 pg mL−1), 5-OH-BDE47 (17.5 pg mL−1) and 4′-OH-BDE49 (12.4 pg mL−1)." @default.
• W2029528089 created "2016-06-24" @default.
• W2029528089 creator A5027775875 @default.
• W2029528089 creator A5036962255 @default.
• W2029528089 creator A5039715503 @default.
• W2029528089 creator A5072396214 @default.
• W2029528089 date "2014-08-01" @default.
• W2029528089 modified "2023-09-26" @default.
• W2029528089 title "Fast liquid chromatographic–tandem mass spectrometric method using mixed-mode phase chromatography and solid phase extraction for the determination of 12 mono-hydroxylated brominated diphenyl ethers in human serum" @default.
• W2029528089 cites W1563949145 @default.
• W2029528089 cites W1974278561 @default.
• W2029528089 cites W1976473606 @default.
• W2029528089 cites W1982821683 @default.
• W2029528089 cites W1991108924 @default.
• W2029528089 cites W2003743209 @default.
• W2029528089 cites W2004604789 @default.
• W2029528089 cites W2011502834 @default.
• W2029528089 cites W2012035884 @default.
• W2029528089 cites W2013972527 @default.
• W2029528089 cites W2022572539 @default.
• W2029528089 cites W2028129869 @default.
• W2029528089 cites W2029482642 @default.
• W2029528089 cites W2030353836 @default.
• W2029528089 cites W2042036197 @default.
• W2029528089 cites W2045774785 @default.
• W2029528089 cites W2045923141 @default.
• W2029528089 cites W2047763386 @default.
• W2029528089 cites W2052129246 @default.
• W2029528089 cites W2059153557 @default.
• W2029528089 cites W2065715323 @default.
• W2029528089 cites W2068476974 @default.
• W2029528089 cites W2070637022 @default.
• W2029528089 cites W2072699912 @default.
• W2029528089 cites W2074289120 @default.
• W2029528089 cites W2075023376 @default.
• W2029528089 cites W2079339436 @default.
• W2029528089 cites W2083421615 @default.
• W2029528089 cites W2084947241 @default.
• W2029528089 cites W2093349340 @default.
• W2029528089 cites W2095567595 @default.
• W2029528089 cites W2098411794 @default.
• W2029528089 cites W2100492886 @default.
• W2029528089 cites W2100929467 @default.
• W2029528089 cites W2103562965 @default.
• W2029528089 cites W2106894335 @default.
• W2029528089 cites W2107763907 @default.
• W2029528089 cites W2109561093 @default.
• W2029528089 cites W2110473114 @default.
• W2029528089 cites W2112496271 @default.
• W2029528089 cites W2123186856 @default.
• W2029528089 cites W2132024398 @default.
• W2029528089 cites W2144679863 @default.
• W2029528089 cites W2163148632 @default.
• W2029528089 cites W2166168987 @default.
• W2029528089 cites W2169178096 @default.
• W2029528089 cites W2327950884 @default.
• W2029528089 cites W2329850252 @default.
• W2029528089 cites W2396689448 @default.
• W2029528089 doi "https://doi.org/10.1016/j.chroma.2014.06.048" @default.
• W2029528089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25001336" @default.
• W2029528089 hasPublicationYear "2014" @default.
• W2029528089 type Work @default.
• W2029528089 sameAs 2029528089 @default.
• W2029528089 citedByCount "12" @default.
• W2029528089 countsByYear W20295280892015 @default.
• W2029528089 countsByYear W20295280892016 @default.
• W2029528089 countsByYear W20295280892017 @default.
• W2029528089 countsByYear W20295280892020 @default.
• W2029528089 countsByYear W20295280892021 @default.
• W2029528089 countsByYear W20295280892022 @default.
• W2029528089 crossrefType "journal-article" @default.
• W2029528089 hasAuthorship W2029528089A5027775875 @default.
• W2029528089 hasAuthorship W2029528089A5036962255 @default.
• W2029528089 hasAuthorship W2029528089A5039715503 @default.
• W2029528089 hasAuthorship W2029528089A5072396214 @default.
• W2029528089 hasConcept C10390740 @default.
• W2029528089 hasConcept C106487976 @default.
• W2029528089 hasConcept C119128265 @default.
• W2029528089 hasConcept C138268822 @default.
• W2029528089 hasConcept C144024400 @default.
• W2029528089 hasConcept C149923435 @default.
• W2029528089 hasConcept C154945302 @default.
• W2029528089 hasConcept C178790620 @default.
• W2029528089 hasConcept C185592680 @default.
• W2029528089 hasConcept C2778576202 @default.
• W2029528089 hasConcept C2780990795 @default.
• W2029528089 hasConcept C2908647359 @default.
• W2029528089 hasConcept C41008148 @default.
• W2029528089 hasConcept C43617362 @default.
• W2029528089 hasConcept C4725764 @default.
• W2029528089 hasConcept C81426234 @default.
• W2029528089 hasConcept C82685317 @default.
• W2029528089 hasConceptScore W2029528089C10390740 @default.
• W2029528089 hasConceptScore W2029528089C106487976 @default.
• W2029528089 hasConceptScore W2029528089C119128265 @default.
• W2029528089 hasConceptScore W2029528089C138268822 @default.
• W2029528089 hasConceptScore W2029528089C144024400 @default.
• W2029528089 hasConceptScore W2029528089C149923435 @default.

• next