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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032893012> ?p ?o ?g. }

• W2032893012 endingPage "1828" @default.
• W2032893012 startingPage "1824" @default.
• W2032893012 abstract "Antimicrobial agents are most often tested against bacteria in the log phase of multiplication to produce the maximum bactericidal effect. In an infection, bacteria may multiply less optimally. We examined the effects of several classes of antimicrobial agents to determine their actions on gram-positive and gram-negative bacteria during nongrowing and slowly growing phases. Only ciprofloxacin and ofloxacin exhibited bactericidal activity against nongrowing gram-negative bacteria, and no antibiotics were bactericidal (3-order-of-magnitude killing) against Staphylococcus aureus. For the very slowly growing gram-negative bacteria studied, gentamicin (an aminoglycoside), imipenem (a carbapenem), meropenem (a carbapenem), ciprofloxacin (a fluoroquinolone), and ofloxacin (a fluoroquinolone) exhibited up to 5.7 orders of magnitude more killing than piperacillin or cefotaxime. This is in contrast to optimally growing bacteria, in which a wide variety of antibiotic classes produced 99.9% killing. For the gram-positive and gram-negative bacteria we examined, antibiotic killing was greatly dependent on the growth rate. The clinical implications of slow killing by chemotherapeutic agents for established bacterial infections and infections involving foreign bodies are unknown." @default.
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• W2032893012 date "1991-09-01" @default.
• W2032893012 modified "2023-10-06" @default.
• W2032893012 title "Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria" @default.
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• W2032893012 doi "https://doi.org/10.1128/aac.35.9.1824" @default.
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