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- W2034006944 abstract "B lymphocyte development is regulated at multiple checkpoints, mediated by signals originating both inside and outside the cell. Two signaling pathways known to be essential in this process are interleukin-7 (IL-7) and the pre-B cell receptor (pBCR). We have shown previously that these signaling pathways intersect functionally. Specifically, response to low concentrations of IL-7 requires pBCR expression. In this report, we identify the ERK/MAP kinase pathway as a key regulatory component of this response. We propose a molecular mechanism for the selective expansion of pBCR(+) precursors and for the culling of inappropriately rearranged pro-B cells." @default.
- W2034006944 created "2016-06-24" @default.
- W2034006944 creator A5052097356 @default.
- W2034006944 creator A5068930495 @default.
- W2034006944 date "2001-10-01" @default.
- W2034006944 modified "2023-10-13" @default.
- W2034006944 title "Pre-B Cell Receptor Signaling Mediates Selective Response to IL-7 at the Pro-B to Pre-B Cell Transition via an ERK/MAP Kinase-Dependent Pathway" @default.
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- W2034006944 doi "https://doi.org/10.1016/s1074-7613(01)00216-3" @default.
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