FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2034631640> ?p ?o ?g. }

• W2034631640 endingPage "e34863" @default.
• W2034631640 startingPage "e34863" @default.
• W2034631640 abstract "MEF2 (A–D) transcription factors govern development, differentiation and maintenance of various cell types including neurons. The role of MEF2 isoforms in the brain has been studied using in vitro manipulations with only MEF2C examined in vivo. In order to understand specific as well as redundant roles of the MEF2 isoforms, we generated brain-specific deletion of MEF2A and found that Mef2aKO mice show normal behavior in a range of paradigms including learning and memory. We next generated Mef2a and Mef2d brain-specific double KO (Mef2a/dDKO) mice and observed deficits in motor coordination and enhanced hippocampal short-term synaptic plasticity, however there were no alterations in learning and memory, Schaffer collateral pathway long-term potentiation, or the number of dendritic spines. Since previous work has established a critical role for MEF2C in hippocampal plasticity, we generated a Mef2a, Mef2c and Mef2d brain-specific triple KO (Mef2a/c/dTKO). Mef2a/c/d TKO mice have early postnatal lethality with increased neuronal apoptosis, indicative of a redundant role for the MEF2 factors in neuronal survival. We examined synaptic plasticity in the intact neurons in the Mef2a/c/d TKO mice and found significant impairments in short-term synaptic plasticity suggesting that MEF2C is the major isoform involved in hippocampal synaptic function. Collectively, these data highlight the key in vivo role of MEF2C isoform in the brain and suggest that MEF2A and MEF2D have only subtle roles in regulating hippocampal synaptic function." @default.
• W2034631640 created "2016-06-24" @default.
• W2034631640 creator A5017288060 @default.
• W2034631640 creator A5024308650 @default.
• W2034631640 creator A5031819667 @default.
• W2034631640 creator A5055334509 @default.
• W2034631640 creator A5055379680 @default.
• W2034631640 creator A5057452045 @default.
• W2034631640 creator A5059395438 @default.
• W2034631640 creator A5068049564 @default.
• W2034631640 creator A5074678907 @default.
• W2034631640 creator A5084182062 @default.
• W2034631640 date "2012-04-09" @default.
• W2034631640 modified "2023-10-16" @default.
• W2034631640 title "In Vivo Analysis of MEF2 Transcription Factors in Synapse Regulation and Neuronal Survival" @default.
• W2034631640 cites W1947596099 @default.
• W2034631640 cites W1963542234 @default.
• W2034631640 cites W1980692621 @default.
• W2034631640 cites W1991979408 @default.
• W2034631640 cites W2011389660 @default.
• W2034631640 cites W2014764883 @default.
• W2034631640 cites W2022814598 @default.
• W2034631640 cites W2044702738 @default.
• W2034631640 cites W2047660382 @default.
• W2034631640 cites W2053726612 @default.
• W2034631640 cites W2059208184 @default.
• W2034631640 cites W2064886074 @default.
• W2034631640 cites W2068244727 @default.
• W2034631640 cites W2070251156 @default.
• W2034631640 cites W2078035790 @default.
• W2034631640 cites W2101544878 @default.
• W2034631640 cites W2112927743 @default.
• W2034631640 cites W2116631863 @default.
• W2034631640 cites W2120629185 @default.
• W2034631640 cites W2148908764 @default.
• W2034631640 cites W2152455387 @default.
• W2034631640 doi "https://doi.org/10.1371/journal.pone.0034863" @default.
• W2034631640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3322166" @default.
• W2034631640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22496871" @default.
• W2034631640 hasPublicationYear "2012" @default.
• W2034631640 type Work @default.
• W2034631640 sameAs 2034631640 @default.
• W2034631640 citedByCount "94" @default.
• W2034631640 countsByYear W20346316402012 @default.
• W2034631640 countsByYear W20346316402013 @default.
• W2034631640 countsByYear W20346316402014 @default.
• W2034631640 countsByYear W20346316402015 @default.
• W2034631640 countsByYear W20346316402016 @default.
• W2034631640 countsByYear W20346316402017 @default.
• W2034631640 countsByYear W20346316402018 @default.
• W2034631640 countsByYear W20346316402019 @default.
• W2034631640 countsByYear W20346316402020 @default.
• W2034631640 countsByYear W20346316402021 @default.
• W2034631640 countsByYear W20346316402022 @default.
• W2034631640 countsByYear W20346316402023 @default.
• W2034631640 crossrefType "journal-article" @default.
• W2034631640 hasAuthorship W2034631640A5017288060 @default.
• W2034631640 hasAuthorship W2034631640A5024308650 @default.
• W2034631640 hasAuthorship W2034631640A5031819667 @default.
• W2034631640 hasAuthorship W2034631640A5055334509 @default.
• W2034631640 hasAuthorship W2034631640A5055379680 @default.
• W2034631640 hasAuthorship W2034631640A5057452045 @default.
• W2034631640 hasAuthorship W2034631640A5059395438 @default.
• W2034631640 hasAuthorship W2034631640A5068049564 @default.
• W2034631640 hasAuthorship W2034631640A5074678907 @default.
• W2034631640 hasAuthorship W2034631640A5084182062 @default.
• W2034631640 hasBestOaLocation W20346316401 @default.
• W2034631640 hasConcept C104317684 @default.
• W2034631640 hasConcept C111936080 @default.
• W2034631640 hasConcept C127445978 @default.
• W2034631640 hasConcept C146291010 @default.
• W2034631640 hasConcept C148762608 @default.
• W2034631640 hasConcept C169760540 @default.
• W2034631640 hasConcept C170493617 @default.
• W2034631640 hasConcept C25274449 @default.
• W2034631640 hasConcept C2781161787 @default.
• W2034631640 hasConcept C51183755 @default.
• W2034631640 hasConcept C53345823 @default.
• W2034631640 hasConcept C54355233 @default.
• W2034631640 hasConcept C86339819 @default.
• W2034631640 hasConcept C86803240 @default.
• W2034631640 hasConcept C95444343 @default.
• W2034631640 hasConcept C98229152 @default.
• W2034631640 hasConceptScore W2034631640C104317684 @default.
• W2034631640 hasConceptScore W2034631640C111936080 @default.
• W2034631640 hasConceptScore W2034631640C127445978 @default.
• W2034631640 hasConceptScore W2034631640C146291010 @default.
• W2034631640 hasConceptScore W2034631640C148762608 @default.
• W2034631640 hasConceptScore W2034631640C169760540 @default.
• W2034631640 hasConceptScore W2034631640C170493617 @default.
• W2034631640 hasConceptScore W2034631640C25274449 @default.
• W2034631640 hasConceptScore W2034631640C2781161787 @default.
• W2034631640 hasConceptScore W2034631640C51183755 @default.
• W2034631640 hasConceptScore W2034631640C53345823 @default.
• W2034631640 hasConceptScore W2034631640C54355233 @default.
• W2034631640 hasConceptScore W2034631640C86339819 @default.
• W2034631640 hasConceptScore W2034631640C86803240 @default.
• W2034631640 hasConceptScore W2034631640C95444343 @default.

• next