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• W2034854042 startingPage "83" @default.
• W2034854042 abstract "Most pH-sensitive drug delivery systems have been reported to respond to wide ranges of pH or target tissues the pH of which vary considerably, whereas these systems are not able to target diseased tissues like inflammatory tissues and tumor cells (pH 6.8) due to the extremely slight differences between pH of normal tissues (pH 7.4) and them. Consequently, ingenious pH-responsive drug delivery systems are desired to target this kind of abnormal tissues. In the present study, we fabricated a novel pH-sensitive drug delivery system with a 22% loading capacity, which released about 65% and 35% model drug in pH 6.8 and 7.4 after 24 h, respectively. In pH 7.4 release medium, chitosan molecules are orderly aggregated state, which efficiently hinder the release of the guest molecules from nanocarriers. However, in pH 6.8 release medium, chitosan chains are heavily and flexibly entangled in gel state, which is good for the release of guest molecules. The drug delivery system could reduce the drug nonspecific reaction with normal cells but remaining the curative effect." @default.
• W2034854042 created "2016-06-24" @default.
• W2034854042 creator A5045126800 @default.
• W2034854042 creator A5084753228 @default.
• W2034854042 date "2012-03-01" @default.
• W2034854042 modified "2023-10-14" @default.
• W2034854042 title "Chitosan enclosed mesoporous silica nanoparticles as drug nano-carriers: Sensitive response to the narrow pH range" @default.
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• W2034854042 doi "https://doi.org/10.1016/j.micromeso.2011.07.023" @default.
• W2034854042 hasPublicationYear "2012" @default.
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