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- W2036252504 endingPage "790" @default.
- W2036252504 startingPage "775" @default.
- W2036252504 abstract "The objective of this review is to review the anaesthetic implications of vasoactive compounds particularly with regard to the cerebral circulation and their clinical importance for the practicing anaesthetist. Material was selected on the basis of validity and application to clinical practice and animal studies were selected only if human studies were lacking. Hypotensive drugs have been used to induce hypotension and in the treatment of intraoperative hypertension during cerebral aneurysm surgery. After subarachnoid haemorrhage, cerebral blood flow is reduced and cerebral vasoreactivity is disturbed which may lead to brain ischaemia. Also, cerebral arterial vasospasm decreases cerebral blood flow, and may lead to delayed ischaemic brain damage which is a major problem after subarachnoid haemorrhage. Recently, the use of induced hypotension has decreased although it is still useful in patients with intraoperative aneurysm rupture, giant cerebral aneurysm, fragile aneurysms and multiple cerebral aneurysms. In this review, a variety of vasodilating agents, prostaglandin E1, sodium nitroprusside, nitroglycerin, trimetaphan, adenosine, calcium antagonists, and inhalational anaesthetics, are discussed for their clinical usefulness. Sodium nitroprusside, nitroglycerin and isoflurane are the drugs of choice for induced hypotension. Prostaglandin E1, nicardipine and nitroglycerin have the advantage that they do not alter carbon dioxide reactivity. Local cerebral blood flow is increased with nitroglycerin, decreased with trimetaphan and unchanged with prostaglandin E1. Intraoperative hypertension is a dangerous complication occurring during cerebral aneurysm surgery, but its treatment in association with subarachnoid haemorrhage is complicated in cases of cerebral arterial vasospasm because fluctuations in cerebral blood flow may be exacerbated. Hypertension should be treated immediately to reduce the risk of rebleeding and intraoperative aneurysmal rupture and the choice of drugs is discussed. Although the use of induced hypotension has declined, the control of arterial blood pressure with vasoactive drugs to reduce the risk of intraoperative cerebral aneurysm rupture is a useful technique. Intraoperative hypertension should be treated immediately but the cerebral vascular effects of each vasodilator should be understood before their use as hypotensive agents." @default.
- W2036252504 created "2016-06-24" @default.
- W2036252504 creator A5073201947 @default.
- W2036252504 date "1993-08-01" @default.
- W2036252504 modified "2023-10-16" @default.
- W2036252504 title "Vasodilators during cerebral aneurysm surgery" @default.
- W2036252504 cites W147820283 @default.
- W2036252504 cites W1512792931 @default.
- W2036252504 cites W1537622435 @default.
- W2036252504 cites W1574261673 @default.
- W2036252504 cites W1874700596 @default.
- W2036252504 cites W1907994445 @default.
- W2036252504 cites W1939989514 @default.
- W2036252504 cites W1948655980 @default.
- W2036252504 cites W1964961543 @default.
- W2036252504 cites W1965941140 @default.
- W2036252504 cites W1966129155 @default.
- W2036252504 cites W1968855217 @default.
- W2036252504 cites W1970199567 @default.
- W2036252504 cites W1970489594 @default.
- W2036252504 cites W1971524300 @default.
- W2036252504 cites W1971932796 @default.
- W2036252504 cites W1973681299 @default.
- W2036252504 cites W1975330935 @default.
- W2036252504 cites W1976349251 @default.
- W2036252504 cites W1981824187 @default.
- W2036252504 cites W1982112819 @default.
- W2036252504 cites W1982972987 @default.
- W2036252504 cites W1983030022 @default.
- W2036252504 cites W1984321579 @default.
- W2036252504 cites W1984689335 @default.
- W2036252504 cites W1984988033 @default.
- W2036252504 cites W1989531273 @default.
- W2036252504 cites W1990849540 @default.
- W2036252504 cites W1991960066 @default.
- W2036252504 cites W1993734922 @default.
- W2036252504 cites W1995196051 @default.
- W2036252504 cites W1998023888 @default.
- W2036252504 cites W1999501075 @default.
- W2036252504 cites W1999897871 @default.
- W2036252504 cites W2007806266 @default.
- W2036252504 cites W2009117762 @default.
- W2036252504 cites W2009126225 @default.
- W2036252504 cites W2013863990 @default.
- W2036252504 cites W2015460321 @default.
- W2036252504 cites W2015820205 @default.
- W2036252504 cites W2016913567 @default.
- W2036252504 cites W2017396797 @default.
- W2036252504 cites W2017604806 @default.
- W2036252504 cites W2018889350 @default.
- W2036252504 cites W2022091686 @default.
- W2036252504 cites W2022465351 @default.
- W2036252504 cites W2022944702 @default.
- W2036252504 cites W2026325123 @default.
- W2036252504 cites W2027071353 @default.
- W2036252504 cites W2028052140 @default.
- W2036252504 cites W2028995385 @default.
- W2036252504 cites W2030248064 @default.
- W2036252504 cites W2030813698 @default.
- W2036252504 cites W2034758230 @default.
- W2036252504 cites W2036463546 @default.
- W2036252504 cites W2038637610 @default.
- W2036252504 cites W2045123624 @default.
- W2036252504 cites W2045619334 @default.
- W2036252504 cites W2046168231 @default.
- W2036252504 cites W2047372408 @default.
- W2036252504 cites W2048657713 @default.
- W2036252504 cites W2049996792 @default.
- W2036252504 cites W2050507288 @default.
- W2036252504 cites W2051679189 @default.
- W2036252504 cites W2052669171 @default.
- W2036252504 cites W2052929848 @default.
- W2036252504 cites W2056275725 @default.
- W2036252504 cites W2056696982 @default.
- W2036252504 cites W2060245641 @default.
- W2036252504 cites W2062675733 @default.
- W2036252504 cites W2063663045 @default.
- W2036252504 cites W2064656708 @default.
- W2036252504 cites W2065399599 @default.
- W2036252504 cites W2068505295 @default.
- W2036252504 cites W2069296442 @default.
- W2036252504 cites W2070461723 @default.
- W2036252504 cites W2073402837 @default.
- W2036252504 cites W2078622617 @default.
- W2036252504 cites W2079211480 @default.
- W2036252504 cites W2079305547 @default.
- W2036252504 cites W2079405518 @default.
- W2036252504 cites W2079883736 @default.
- W2036252504 cites W2085787877 @default.
- W2036252504 cites W2087065340 @default.
- W2036252504 cites W2087212474 @default.
- W2036252504 cites W2087716966 @default.
- W2036252504 cites W2089258817 @default.
- W2036252504 cites W2094081435 @default.
- W2036252504 cites W2095808759 @default.
- W2036252504 cites W2097148037 @default.
- W2036252504 cites W2099395762 @default.
- W2036252504 cites W2100446760 @default.