FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036703314> ?p ?o ?g. }

• W2036703314 endingPage "332" @default.
• W2036703314 startingPage "313" @default.
• W2036703314 abstract "The ability of enterobacteria to become UV-tolerant is important because such tolerance may enable organisms to resist irradiation in the environment, in water treatment, in shell-fish, in stages of food processing, and at locations in the domestic, commercial and hospital environment The mechanism for regulation of tolerance induction and SOS response induction has been studied for many years, and is well understood, except for the early stages of induction. Such early stages, namely sensing of the stimulus (UV irradiation) and the way in which such sensing leads to signal production, have until now been poorly understood. The claim has been made that DNA is the sensor and that either damage to DNA or production of SS regions in DNA (following interaction of UV with DNA) triggers the signal that sets in train RecA activation and other stages of tolerance induction. This claimed induction mechanism is a classical one in the sense that it involves intracellular sensing (by DNA) of the stressing stimulus (UV), and production of an intracellular signalling molecule. It is not, however, firmly established as the mechanism for initiation of UV tolerance induction and SOS response induction. The results reviewed here give firm evidence for a different and unique mechanism for sensing of UV and production of the signal. These results establish without doubt that, for UV tolerance induction, the UV sensor is an extracellular protein, which is a UV tolerance-specific extracellular sensing component (ESC). This component is formed by unstressed cells and on interacting with the stimulus (UV) in the medium, is converted to the tolerance induction signalling molecule, which is a UV tolerance-specific extracellular induction component (EIC). It is this extracellular signal which interacts with the sensitive organisms and triggers tolerance induction. This pair of extracellular components (ECs) may offer the only means of switching-on such tolerance induction; certainly they offer the only known way for early warning to be given of impending UV challenge. Thus, the EIC can diffuse from a region of UV stress to a stress-free region and there warn organisms of impending stress and prepare them to resist it. As indicated here, UV irradiation not only induces UV tolerance, but also switches-on acid tolerance, alkali tolerance and thermotolerance responses. The fact that all three responses involve ESC/EIC pairs strongly supports the view that functioning of such EC pairs form the major, if not the only, means for UV tolerance induction. The UV tolerance-specific ESC can detect other stresses and becomes activated, leading to cross-tolerance responses. Of particular interest, this ESC acts as a biological thermometer, detecting increases in temperature, such increases leading to gradually increasing formation of the EIC and, accordingly, gradual increases in UV tolerance. This UV tolerance-specific ESC can also detect other stresses e.g. acting as a pH sensor. In all cases, on activation, the EIC formed (from this specific ESC) only induces UV tolerance. It is proposed that the interaction of EICs with stress-sensitive organisms should be examined, and it is suggested that such EICs may, directly or indirectly, interact with and activate the same stress response regulators as are used to detect internal stressors and which, on activation, also trigger the switching-on of stress responses. For example, EICs either a in a protonated or oxidised state (formed by activation of ESCs by H+ or H2O2) or b produced by irradiation, may lead to protonation or oxidation or other forms of activation of the appropriate regulator (e.g. Fur or OxyR or RecA etc), leading to response induction." @default.
• W2036703314 created "2016-06-24" @default.
• W2036703314 creator A5043337143 @default.
• W2036703314 date "2003-11-01" @default.
• W2036703314 modified "2023-09-25" @default.
• W2036703314 title "Uv Radiation-Induced Enterobacterial Responses, Other Processes that Influence uv Tolerance and Likely Environmental Significance" @default.
• W2036703314 cites W1497274060 @default.
• W2036703314 cites W1498264772 @default.
• W2036703314 cites W1511000063 @default.
• W2036703314 cites W1551452913 @default.
• W2036703314 cites W1568193923 @default.
• W2036703314 cites W1576104289 @default.
• W2036703314 cites W1579105736 @default.
• W2036703314 cites W1745024876 @default.
• W2036703314 cites W1981317526 @default.
• W2036703314 cites W1987229501 @default.
• W2036703314 cites W1987808807 @default.
• W2036703314 cites W1993734375 @default.
• W2036703314 cites W2006234396 @default.
• W2036703314 cites W2015013684 @default.
• W2036703314 cites W2023910328 @default.
• W2036703314 cites W2036924448 @default.
• W2036703314 cites W2051268551 @default.
• W2036703314 cites W2055179428 @default.
• W2036703314 cites W2069344856 @default.
• W2036703314 cites W2072922005 @default.
• W2036703314 cites W2076593723 @default.
• W2036703314 cites W2076996398 @default.
• W2036703314 cites W2084460529 @default.
• W2036703314 cites W2111169680 @default.
• W2036703314 cites W2118128934 @default.
• W2036703314 cites W2121656246 @default.
• W2036703314 cites W2134122952 @default.
• W2036703314 cites W2137178857 @default.
• W2036703314 cites W2159827502 @default.
• W2036703314 cites W2168355088 @default.
• W2036703314 cites W2414168391 @default.
• W2036703314 doi "https://doi.org/10.3184/003685003783238644" @default.
• W2036703314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15508895" @default.
• W2036703314 hasPublicationYear "2003" @default.
• W2036703314 type Work @default.
• W2036703314 sameAs 2036703314 @default.
• W2036703314 citedByCount "19" @default.
• W2036703314 countsByYear W20367033142012 @default.
• W2036703314 countsByYear W20367033142013 @default.
• W2036703314 countsByYear W20367033142014 @default.
• W2036703314 countsByYear W20367033142015 @default.
• W2036703314 countsByYear W20367033142016 @default.
• W2036703314 countsByYear W20367033142017 @default.
• W2036703314 crossrefType "journal-article" @default.
• W2036703314 hasAuthorship W2036703314A5043337143 @default.
• W2036703314 hasBestOaLocation W20367033141 @default.
• W2036703314 hasConcept C12554922 @default.
• W2036703314 hasConcept C134935766 @default.
• W2036703314 hasConcept C143425029 @default.
• W2036703314 hasConcept C15744967 @default.
• W2036703314 hasConcept C185592680 @default.
• W2036703314 hasConcept C2779918689 @default.
• W2036703314 hasConcept C2780852648 @default.
• W2036703314 hasConcept C28406088 @default.
• W2036703314 hasConcept C542102704 @default.
• W2036703314 hasConcept C54355233 @default.
• W2036703314 hasConcept C552990157 @default.
• W2036703314 hasConcept C79879829 @default.
• W2036703314 hasConcept C86803240 @default.
• W2036703314 hasConcept C95444343 @default.
• W2036703314 hasConceptScore W2036703314C12554922 @default.
• W2036703314 hasConceptScore W2036703314C134935766 @default.
• W2036703314 hasConceptScore W2036703314C143425029 @default.
• W2036703314 hasConceptScore W2036703314C15744967 @default.
• W2036703314 hasConceptScore W2036703314C185592680 @default.
• W2036703314 hasConceptScore W2036703314C2779918689 @default.
• W2036703314 hasConceptScore W2036703314C2780852648 @default.
• W2036703314 hasConceptScore W2036703314C28406088 @default.
• W2036703314 hasConceptScore W2036703314C542102704 @default.
• W2036703314 hasConceptScore W2036703314C54355233 @default.
• W2036703314 hasConceptScore W2036703314C552990157 @default.
• W2036703314 hasConceptScore W2036703314C79879829 @default.
• W2036703314 hasConceptScore W2036703314C86803240 @default.
• W2036703314 hasConceptScore W2036703314C95444343 @default.
• W2036703314 hasIssue "4" @default.
• W2036703314 hasLocation W20367033141 @default.
• W2036703314 hasLocation W20367033142 @default.
• W2036703314 hasOpenAccess W2036703314 @default.
• W2036703314 hasPrimaryLocation W20367033141 @default.
• W2036703314 hasRelatedWork W101867907 @default.
• W2036703314 hasRelatedWork W1999730113 @default.
• W2036703314 hasRelatedWork W2014034588 @default.
• W2036703314 hasRelatedWork W2030915532 @default.
• W2036703314 hasRelatedWork W2085920417 @default.
• W2036703314 hasRelatedWork W2113632086 @default.
• W2036703314 hasRelatedWork W2408647218 @default.
• W2036703314 hasRelatedWork W2797952716 @default.
• W2036703314 hasRelatedWork W3023076629 @default.
• W2036703314 hasRelatedWork W3180324226 @default.
• W2036703314 hasVolume "86" @default.
• W2036703314 isParatext "false" @default.
• W2036703314 isRetracted "false" @default.

• next