FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037747593> ?p ?o ?g. }

• W2037747593 endingPage "4026" @default.
• W2037747593 startingPage "4018" @default.
• W2037747593 abstract "ABSTRACT Drug-induced inhibition of fungal growth is used in the diagnostic laboratory to predict therapeutic efficacy but is relatively slow, and determination of endpoints can be problematic. Nuclear magnetic resonance (NMR) spectroscopy identifies the metabolic complement of microorganisms while monitoring utilization of constituents of the incubation medium. This technique may provide a rapid and objective indicator of antifungal effects. We evaluated the effects of caspofungin, amphotericin B (AMB), and voriconazole on metabolic profiles of yeast species cultured in RPMI-2% glucose-morpholinepropanesulfonic acid buffer in microtiter plates in a proof-of-principle study. 1 H NMR spectra were obtained using Bruker NMR spectrometers at 1 H frequencies of 600 and 360 MHz. Metabolites were identified by two-dimensional correlation NMR spectra, and relative peak integrals were calculated from one-dimensional 1 H NMR spectra. MICs were determined by a modification of the Clinical and Laboratory Standards Institute broth microdilution method M27-A. Utilization of glucose and branched-chain and aromatic amino acid substrates was accompanied by fungal production of acetate, acetaldehyde, ethanol, formate, fumarate, glycerol, lactate, pyruvate, and succinate. Clear-cut metabolic endpoints indicating a greater than 50% reduction in substrate utilization and fungal metabolite production which correlated with MICs were noted at 16 and 24 h for all three drugs. At 8 h, reductions of greater than 50% for selected metabolites were noted for caspofungin and AMB. Direct NMR-based observation of metabolic alterations in yeast cultures reveals changes in key metabolic pathways and should be evaluated formally as a rapid technique for determining susceptibility to antifungal drugs." @default.
• W2037747593 created "2016-06-24" @default.
• W2037747593 creator A5002951013 @default.
• W2037747593 creator A5004293803 @default.
• W2037747593 creator A5022370216 @default.
• W2037747593 creator A5046564619 @default.
• W2037747593 creator A5068841601 @default.
• W2037747593 creator A5069972235 @default.
• W2037747593 creator A5081563103 @default.
• W2037747593 date "2006-12-01" @default.
• W2037747593 modified "2023-10-04" @default.
• W2037747593 title "Antifungal Effects on Metabolite Profiles of Medically Important Yeast Species Measured by Nuclear Magnetic Resonance Spectroscopy" @default.
• W2037747593 cites W1811669891 @default.
• W2037747593 cites W1981059006 @default.
• W2037747593 cites W1994426057 @default.
• W2037747593 cites W2027546225 @default.
• W2037747593 cites W2093682425 @default.
• W2037747593 cites W2099816638 @default.
• W2037747593 cites W2108249211 @default.
• W2037747593 cites W2109846421 @default.
• W2037747593 cites W2114733271 @default.
• W2037747593 cites W2122704841 @default.
• W2037747593 cites W2136753636 @default.
• W2037747593 cites W2138433856 @default.
• W2037747593 cites W2145937697 @default.
• W2037747593 cites W2149857689 @default.
• W2037747593 cites W2151342294 @default.
• W2037747593 cites W2151981655 @default.
• W2037747593 cites W2159799484 @default.
• W2037747593 cites W2162007379 @default.
• W2037747593 cites W2162638547 @default.
• W2037747593 cites W2170975984 @default.
• W2037747593 cites W2171621990 @default.
• W2037747593 doi "https://doi.org/10.1128/aac.00439-06" @default.
• W2037747593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1693988" @default.
• W2037747593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16982786" @default.
• W2037747593 hasPublicationYear "2006" @default.
• W2037747593 type Work @default.
• W2037747593 sameAs 2037747593 @default.
• W2037747593 citedByCount "19" @default.
• W2037747593 countsByYear W20377475932013 @default.
• W2037747593 countsByYear W20377475932014 @default.
• W2037747593 countsByYear W20377475932015 @default.
• W2037747593 countsByYear W20377475932016 @default.
• W2037747593 countsByYear W20377475932019 @default.
• W2037747593 countsByYear W20377475932020 @default.
• W2037747593 countsByYear W20377475932022 @default.
• W2037747593 countsByYear W20377475932023 @default.
• W2037747593 crossrefType "journal-article" @default.
• W2037747593 hasAuthorship W2037747593A5002951013 @default.
• W2037747593 hasAuthorship W2037747593A5004293803 @default.
• W2037747593 hasAuthorship W2037747593A5022370216 @default.
• W2037747593 hasAuthorship W2037747593A5046564619 @default.
• W2037747593 hasAuthorship W2037747593A5068841601 @default.
• W2037747593 hasAuthorship W2037747593A5069972235 @default.
• W2037747593 hasAuthorship W2037747593A5081563103 @default.
• W2037747593 hasBestOaLocation W20377475931 @default.
• W2037747593 hasConcept C161790260 @default.
• W2037747593 hasConcept C185592680 @default.
• W2037747593 hasConcept C2777477808 @default.
• W2037747593 hasConcept C2779222958 @default.
• W2037747593 hasConcept C2779548794 @default.
• W2037747593 hasConcept C2779629538 @default.
• W2037747593 hasConcept C2780178953 @default.
• W2037747593 hasConcept C2780402444 @default.
• W2037747593 hasConcept C43617362 @default.
• W2037747593 hasConcept C55493867 @default.
• W2037747593 hasConcept C66974803 @default.
• W2037747593 hasConcept C71240020 @default.
• W2037747593 hasConcept C86803240 @default.
• W2037747593 hasConcept C89423630 @default.
• W2037747593 hasConceptScore W2037747593C161790260 @default.
• W2037747593 hasConceptScore W2037747593C185592680 @default.
• W2037747593 hasConceptScore W2037747593C2777477808 @default.
• W2037747593 hasConceptScore W2037747593C2779222958 @default.
• W2037747593 hasConceptScore W2037747593C2779548794 @default.
• W2037747593 hasConceptScore W2037747593C2779629538 @default.
• W2037747593 hasConceptScore W2037747593C2780178953 @default.
• W2037747593 hasConceptScore W2037747593C2780402444 @default.
• W2037747593 hasConceptScore W2037747593C43617362 @default.
• W2037747593 hasConceptScore W2037747593C55493867 @default.
• W2037747593 hasConceptScore W2037747593C66974803 @default.
• W2037747593 hasConceptScore W2037747593C71240020 @default.
• W2037747593 hasConceptScore W2037747593C86803240 @default.
• W2037747593 hasConceptScore W2037747593C89423630 @default.
• W2037747593 hasIssue "12" @default.
• W2037747593 hasLocation W20377475931 @default.
• W2037747593 hasLocation W20377475932 @default.
• W2037747593 hasLocation W20377475933 @default.
• W2037747593 hasLocation W20377475934 @default.
• W2037747593 hasOpenAccess W2037747593 @default.
• W2037747593 hasPrimaryLocation W20377475931 @default.
• W2037747593 hasRelatedWork W1901618243 @default.
• W2037747593 hasRelatedWork W2033300417 @default.
• W2037747593 hasRelatedWork W2054977142 @default.
• W2037747593 hasRelatedWork W2076755544 @default.
• W2037747593 hasRelatedWork W2079599846 @default.
• W2037747593 hasRelatedWork W2090251870 @default.

• next