FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038895087> ?p ?o ?g. }

• W2038895087 endingPage "e76" @default.
• W2038895087 startingPage "e76" @default.
• W2038895087 abstract "The majority of efforts to increase specificity or sensitivity in biosensors result in trade-offs with little to no gain in overall accuracy. This is because a biosensor cannot be more accurate than the affinity interaction it is based on. Accordingly, we have developed a new class of reagents based on mathematical principles of cooperativity to enhance the accuracy of the affinity interaction. Tentacle probes (TPs) have a hairpin structure similar to molecular beacons (MBs) for enhanced specificity, but are modified by the addition of a capture probe for increased kinetics and affinity. They produce kinetic rate constants up to 200-fold faster than MB with corresponding stem strengths. Concentration-independent specificity was observed with no false positives at up to 1 mM concentrations of variant analyte. In contrast, MBs were concentration dependent and experienced false positives above 3.88 μM of variant analyte. The fast kinetics of this label-free reagent may prove important for extraction efficiency, hence sensitivity and detection time, in microfluidic assays. The concentration-independent specificity of TPs may prove extremely useful in assays where starting concentrations and purities are unknown as would be the case in bioterror or clinical point of care diagnostics." @default.
• W2038895087 created "2016-06-24" @default.
• W2038895087 creator A5039938601 @default.
• W2038895087 creator A5048388860 @default.
• W2038895087 creator A5079091432 @default.
• W2038895087 date "2007-04-22" @default.
• W2038895087 modified "2023-10-17" @default.
• W2038895087 title "Tentacle probes: eliminating false positives without sacrificing sensitivity" @default.
• W2038895087 cites W1582593681 @default.
• W2038895087 cites W1964006504 @default.
• W2038895087 cites W1971128501 @default.
• W2038895087 cites W1976237916 @default.
• W2038895087 cites W1990094816 @default.
• W2038895087 cites W1996491588 @default.
• W2038895087 cites W2007272508 @default.
• W2038895087 cites W2011500156 @default.
• W2038895087 cites W2015316514 @default.
• W2038895087 cites W2017829077 @default.
• W2038895087 cites W2021755139 @default.
• W2038895087 cites W2028284457 @default.
• W2038895087 cites W2032522602 @default.
• W2038895087 cites W2039696994 @default.
• W2038895087 cites W2048273174 @default.
• W2038895087 cites W2061404407 @default.
• W2038895087 cites W2070721758 @default.
• W2038895087 cites W2100404753 @default.
• W2038895087 cites W2109007387 @default.
• W2038895087 cites W2126818937 @default.
• W2038895087 cites W2126851572 @default.
• W2038895087 cites W2132796188 @default.
• W2038895087 cites W2141157874 @default.
• W2038895087 cites W2142149155 @default.
• W2038895087 cites W2145061993 @default.
• W2038895087 cites W2148344506 @default.
• W2038895087 cites W2152585699 @default.
• W2038895087 cites W2157309845 @default.
• W2038895087 cites W2158040269 @default.
• W2038895087 cites W2167813002 @default.
• W2038895087 cites W2169022251 @default.
• W2038895087 cites W2288565846 @default.
• W2038895087 cites W2048403918 @default.
• W2038895087 doi "https://doi.org/10.1093/nar/gkm113" @default.
• W2038895087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1904288" @default.
• W2038895087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17517788" @default.
• W2038895087 hasPublicationYear "2007" @default.
• W2038895087 type Work @default.
• W2038895087 sameAs 2038895087 @default.
• W2038895087 citedByCount "22" @default.
• W2038895087 countsByYear W20388950872012 @default.
• W2038895087 countsByYear W20388950872014 @default.
• W2038895087 countsByYear W20388950872015 @default.
• W2038895087 countsByYear W20388950872016 @default.
• W2038895087 countsByYear W20388950872017 @default.
• W2038895087 countsByYear W20388950872018 @default.
• W2038895087 countsByYear W20388950872021 @default.
• W2038895087 crossrefType "journal-article" @default.
• W2038895087 hasAuthorship W2038895087A5039938601 @default.
• W2038895087 hasAuthorship W2038895087A5048388860 @default.
• W2038895087 hasAuthorship W2038895087A5079091432 @default.
• W2038895087 hasBestOaLocation W20388950871 @default.
• W2038895087 hasConcept C10390740 @default.
• W2038895087 hasConcept C112789634 @default.
• W2038895087 hasConcept C119203544 @default.
• W2038895087 hasConcept C121332964 @default.
• W2038895087 hasConcept C12554922 @default.
• W2038895087 hasConcept C129312508 @default.
• W2038895087 hasConcept C147789679 @default.
• W2038895087 hasConcept C148898269 @default.
• W2038895087 hasConcept C154945302 @default.
• W2038895087 hasConcept C160756335 @default.
• W2038895087 hasConcept C166014724 @default.
• W2038895087 hasConcept C185592680 @default.
• W2038895087 hasConcept C21951064 @default.
• W2038895087 hasConcept C40875361 @default.
• W2038895087 hasConcept C41008148 @default.
• W2038895087 hasConcept C43617362 @default.
• W2038895087 hasConcept C552990157 @default.
• W2038895087 hasConcept C55493867 @default.
• W2038895087 hasConcept C62520636 @default.
• W2038895087 hasConcept C64869954 @default.
• W2038895087 hasConcept C70721500 @default.
• W2038895087 hasConcept C86803240 @default.
• W2038895087 hasConcept C95922358 @default.
• W2038895087 hasConceptScore W2038895087C10390740 @default.
• W2038895087 hasConceptScore W2038895087C112789634 @default.
• W2038895087 hasConceptScore W2038895087C119203544 @default.
• W2038895087 hasConceptScore W2038895087C121332964 @default.
• W2038895087 hasConceptScore W2038895087C12554922 @default.
• W2038895087 hasConceptScore W2038895087C129312508 @default.
• W2038895087 hasConceptScore W2038895087C147789679 @default.
• W2038895087 hasConceptScore W2038895087C148898269 @default.
• W2038895087 hasConceptScore W2038895087C154945302 @default.
• W2038895087 hasConceptScore W2038895087C160756335 @default.
• W2038895087 hasConceptScore W2038895087C166014724 @default.
• W2038895087 hasConceptScore W2038895087C185592680 @default.
• W2038895087 hasConceptScore W2038895087C21951064 @default.
• W2038895087 hasConceptScore W2038895087C40875361 @default.
• W2038895087 hasConceptScore W2038895087C41008148 @default.

• next