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• W2039968181 abstract "We report the computer-aided design, chemical synthesis, and biological evaluation of a novel family of δ opioid receptor (DOR) antagonists containing a 1,2,4-triazole core structure that are structurally distinct from other known opioid receptor active ligands. Among those δ antagonists sharing this core structure, 8 exhibited strong binding affinity (Ki = 50 nM) for the DOR and appreciable selectivity for δ over μ and κ opioid receptors (δ/μ = 80; δ/κ > 200)." @default.
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• W2039968181 date "2006-06-21" @default.
• W2039968181 modified "2023-09-23" @default.
• W2039968181 title "Discovery of Novel Triazole-Based Opioid Receptor Antagonists" @default.
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• W2039968181 doi "https://doi.org/10.1021/jm0601250" @default.
• W2039968181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2693423" @default.
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