Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040136700> ?p ?o ?g. }
- W2040136700 endingPage "1233" @default.
- W2040136700 startingPage "1225" @default.
- W2040136700 abstract "Objective: Severe inflammation and sepsis remain a serious clinical challenge worldwide. Despite modern supportive medicine and an improved understanding of the underlying pathophysiology, mortality rates remain high in patients suffering from this severe inflammatory process. The often excess production of pro- and anti-inflammatory cytokines frequently found in the circulation of septic patients has stimulated the search for reliable inflammatory mediators that can be used for the diagnosis and prediction of clinical outcome. Interleukin (IL)-18, formerly termed interferon-γ inducing factor, is a pro-inflammatory and Th1 cytokine suggested to play a significant role in the pathogenesis of this disease. This review focuses on our current understanding of the pro-inflammatory cytokine, IL-18, and its potentially unique role in sepsis. Methods: Bibliographic search of the most recent literature (1995–2005) relating to IL-18 and its role in inflammatory diseases, with emphasis on its pathophysiological importance in sepsis. In addition, a summary of the author’s own experimental data from this particular field of research set in the context of current knowledge regarding IL-18. Results and Conclusions: Several studies have shown elevated plasma IL-18 concentrations to be associated with poor clinical outcome in severe inflammatory and septic conditions. Moreover, a significant increase in IL-18 concentrations has been shown to discriminate between Gram-positive and Gram-negative related sepsis, and, thus, may potentially augment existing diagnostic tools. Biological neutralization of IL-18 via caspase-1 intervention or through the administration of IL-18-binding protein has been promulgated as a promising therapeutic approach, but additional studies are required to evaluate its full potential in acute inflammatory diseases." @default.
- W2040136700 created "2016-06-24" @default.
- W2040136700 creator A5006285569 @default.
- W2040136700 creator A5078361446 @default.
- W2040136700 creator A5081164839 @default.
- W2040136700 date "2006-04-01" @default.
- W2040136700 modified "2023-09-30" @default.
- W2040136700 title "Interleukin-18: A novel prognostic cytokine in bacteria-induced sepsis" @default.
- W2040136700 cites W127313292 @default.
- W2040136700 cites W1508220421 @default.
- W2040136700 cites W1512082009 @default.
- W2040136700 cites W1543281579 @default.
- W2040136700 cites W1543457854 @default.
- W2040136700 cites W1566974294 @default.
- W2040136700 cites W1602083480 @default.
- W2040136700 cites W1621354558 @default.
- W2040136700 cites W1643888758 @default.
- W2040136700 cites W1940973248 @default.
- W2040136700 cites W1966999651 @default.
- W2040136700 cites W1968891062 @default.
- W2040136700 cites W1970266916 @default.
- W2040136700 cites W1972692948 @default.
- W2040136700 cites W1975032025 @default.
- W2040136700 cites W1976320059 @default.
- W2040136700 cites W1977135749 @default.
- W2040136700 cites W1978290962 @default.
- W2040136700 cites W1981109162 @default.
- W2040136700 cites W1990266088 @default.
- W2040136700 cites W1990406026 @default.
- W2040136700 cites W1992987958 @default.
- W2040136700 cites W1997720968 @default.
- W2040136700 cites W1997985212 @default.
- W2040136700 cites W2000685330 @default.
- W2040136700 cites W2001998616 @default.
- W2040136700 cites W2002824553 @default.
- W2040136700 cites W2006288082 @default.
- W2040136700 cites W2008307832 @default.
- W2040136700 cites W2009286881 @default.
- W2040136700 cites W2009550948 @default.
- W2040136700 cites W2013460515 @default.
- W2040136700 cites W2019383068 @default.
- W2040136700 cites W2019664188 @default.
- W2040136700 cites W2019865197 @default.
- W2040136700 cites W2020574822 @default.
- W2040136700 cites W2022942008 @default.
- W2040136700 cites W2023537023 @default.
- W2040136700 cites W2025906560 @default.
- W2040136700 cites W2028959153 @default.
- W2040136700 cites W2032929318 @default.
- W2040136700 cites W2033028058 @default.
- W2040136700 cites W2033300203 @default.
- W2040136700 cites W2033777084 @default.
- W2040136700 cites W2039429803 @default.
- W2040136700 cites W2039820190 @default.
- W2040136700 cites W2041077071 @default.
- W2040136700 cites W2041170922 @default.
- W2040136700 cites W2041928346 @default.
- W2040136700 cites W2042284973 @default.
- W2040136700 cites W2044212900 @default.
- W2040136700 cites W2047672114 @default.
- W2040136700 cites W2052117755 @default.
- W2040136700 cites W2052895824 @default.
- W2040136700 cites W2053247337 @default.
- W2040136700 cites W2054260525 @default.
- W2040136700 cites W2056103424 @default.
- W2040136700 cites W2056760893 @default.
- W2040136700 cites W2060282267 @default.
- W2040136700 cites W2061091814 @default.
- W2040136700 cites W2064812148 @default.
- W2040136700 cites W2068162171 @default.
- W2040136700 cites W2069396247 @default.
- W2040136700 cites W2069792691 @default.
- W2040136700 cites W2070519352 @default.
- W2040136700 cites W2072072808 @default.
- W2040136700 cites W2074030473 @default.
- W2040136700 cites W2076563855 @default.
- W2040136700 cites W2079110418 @default.
- W2040136700 cites W2083530598 @default.
- W2040136700 cites W2086250644 @default.
- W2040136700 cites W2090439142 @default.
- W2040136700 cites W2092800788 @default.
- W2040136700 cites W2095698281 @default.
- W2040136700 cites W2096215604 @default.
- W2040136700 cites W2102943702 @default.
- W2040136700 cites W2104450960 @default.
- W2040136700 cites W2105249258 @default.
- W2040136700 cites W2106530602 @default.
- W2040136700 cites W2111228195 @default.
- W2040136700 cites W2112919322 @default.
- W2040136700 cites W2120886013 @default.
- W2040136700 cites W2125309974 @default.
- W2040136700 cites W2127314810 @default.
- W2040136700 cites W2128094247 @default.
- W2040136700 cites W2128413447 @default.
- W2040136700 cites W2138582489 @default.
- W2040136700 cites W2138904389 @default.
- W2040136700 cites W2139630902 @default.
- W2040136700 cites W2143682143 @default.