FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040367392> ?p ?o ?g. }

• W2040367392 endingPage "1264" @default.
• W2040367392 startingPage "1251" @default.
• W2040367392 abstract "In the absence of the de novo purine nucleotide biosynthetic pathway in parasitic protozoa, purine salvage is of primary importance for parasite survival. Enzymes of the salvage pathway are, therefore, good targets for anti-parasitic drugs. Adenylosuccinate synthetase (AdSS), catalysing the first committed step in the synthesis of AMP from IMP, is a potential target for anti-protozoal chemotherapy. We report here the crystal structure of adenylosuccinate synthetase from the malaria parasite, Plasmodium falciparum, complexed to 6-phosphoryl IMP, GDP, Mg2+ and the aspartate analogue, hadacidin at 2 Å resolution. The overall architecture of P. falciparum AdSS (PfAdSS) is similar to the known structures from Escherichia coli, mouse and plants. Differences in substrate interactions seen in this structure provide a plausible explanation for the kinetic differences between PfAdSS and the enzyme from other species. Additional hydrogen bonding interactions of the protein with GDP may account for the ordered binding of substrates to the enzyme. The dimer interface of PfAdSS is also different, with a pronounced excess of positively charged residues. Differences highlighted here provide a basis for the design of species-specific inhibitors of the enzyme." @default.
• W2040367392 created "2016-06-24" @default.
• W2040367392 creator A5024273182 @default.
• W2040367392 creator A5025130832 @default.
• W2040367392 creator A5027410391 @default.
• W2040367392 creator A5031698284 @default.
• W2040367392 creator A5060492617 @default.
• W2040367392 creator A5063744672 @default.
• W2040367392 creator A5074116959 @default.
• W2040367392 date "2004-01-01" @default.
• W2040367392 modified "2023-09-26" @default.
• W2040367392 title "Crystal Structure of Fully Ligated Adenylosuccinate Synthetase from Plasmodium falciparum" @default.
• W2040367392 cites W12984822 @default.
• W2040367392 cites W1539796472 @default.
• W2040367392 cites W1563191931 @default.
• W2040367392 cites W1581897505 @default.
• W2040367392 cites W1600838929 @default.
• W2040367392 cites W1876118699 @default.
• W2040367392 cites W1967194316 @default.
• W2040367392 cites W1970644248 @default.
• W2040367392 cites W1971660446 @default.
• W2040367392 cites W1972131774 @default.
• W2040367392 cites W1973947874 @default.
• W2040367392 cites W1995017064 @default.
• W2040367392 cites W2001641653 @default.
• W2040367392 cites W2013083986 @default.
• W2040367392 cites W2013817482 @default.
• W2040367392 cites W2019851585 @default.
• W2040367392 cites W2028231353 @default.
• W2040367392 cites W2031573500 @default.
• W2040367392 cites W2040482288 @default.
• W2040367392 cites W2045007741 @default.
• W2040367392 cites W2047229122 @default.
• W2040367392 cites W2047873079 @default.
• W2040367392 cites W2049125285 @default.
• W2040367392 cites W2055989425 @default.
• W2040367392 cites W2062450780 @default.
• W2040367392 cites W2064188757 @default.
• W2040367392 cites W2064589373 @default.
• W2040367392 cites W2067887310 @default.
• W2040367392 cites W2080476827 @default.
• W2040367392 cites W2080528351 @default.
• W2040367392 cites W2093491670 @default.
• W2040367392 cites W2117799383 @default.
• W2040367392 cites W2120399525 @default.
• W2040367392 cites W2139065251 @default.
• W2040367392 cites W2150269465 @default.
• W2040367392 cites W4214926555 @default.
• W2040367392 doi "https://doi.org/10.1016/j.jmb.2003.11.036" @default.
• W2040367392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14729341" @default.
• W2040367392 hasPublicationYear "2004" @default.
• W2040367392 type Work @default.
• W2040367392 sameAs 2040367392 @default.
• W2040367392 citedByCount "38" @default.
• W2040367392 countsByYear W20403673922012 @default.
• W2040367392 countsByYear W20403673922013 @default.
• W2040367392 countsByYear W20403673922014 @default.
• W2040367392 countsByYear W20403673922015 @default.
• W2040367392 countsByYear W20403673922016 @default.
• W2040367392 countsByYear W20403673922018 @default.
• W2040367392 countsByYear W20403673922019 @default.
• W2040367392 countsByYear W20403673922020 @default.
• W2040367392 countsByYear W20403673922022 @default.
• W2040367392 countsByYear W20403673922023 @default.
• W2040367392 crossrefType "journal-article" @default.
• W2040367392 hasAuthorship W2040367392A5024273182 @default.
• W2040367392 hasAuthorship W2040367392A5025130832 @default.
• W2040367392 hasAuthorship W2040367392A5027410391 @default.
• W2040367392 hasAuthorship W2040367392A5031698284 @default.
• W2040367392 hasAuthorship W2040367392A5060492617 @default.
• W2040367392 hasAuthorship W2040367392A5063744672 @default.
• W2040367392 hasAuthorship W2040367392A5074116959 @default.
• W2040367392 hasConcept C104317684 @default.
• W2040367392 hasConcept C169586020 @default.
• W2040367392 hasConcept C178790620 @default.
• W2040367392 hasConcept C181199279 @default.
• W2040367392 hasConcept C185592680 @default.
• W2040367392 hasConcept C194101687 @default.
• W2040367392 hasConcept C203014093 @default.
• W2040367392 hasConcept C2776476023 @default.
• W2040367392 hasConcept C2778048844 @default.
• W2040367392 hasConcept C2778371730 @default.
• W2040367392 hasConcept C2779546866 @default.
• W2040367392 hasConcept C512185932 @default.
• W2040367392 hasConcept C55493867 @default.
• W2040367392 hasConcept C71240020 @default.
• W2040367392 hasConcept C86803240 @default.
• W2040367392 hasConceptScore W2040367392C104317684 @default.
• W2040367392 hasConceptScore W2040367392C169586020 @default.
• W2040367392 hasConceptScore W2040367392C178790620 @default.
• W2040367392 hasConceptScore W2040367392C181199279 @default.
• W2040367392 hasConceptScore W2040367392C185592680 @default.
• W2040367392 hasConceptScore W2040367392C194101687 @default.
• W2040367392 hasConceptScore W2040367392C203014093 @default.
• W2040367392 hasConceptScore W2040367392C2776476023 @default.
• W2040367392 hasConceptScore W2040367392C2778048844 @default.
• W2040367392 hasConceptScore W2040367392C2778371730 @default.
• W2040367392 hasConceptScore W2040367392C2779546866 @default.

• next