Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040981010> ?p ?o ?g. }
- W2040981010 endingPage "321" @default.
- W2040981010 startingPage "316" @default.
- W2040981010 abstract "Reserpine-induced orofacial dyskinesia is a model that shares some mechanists’ aspects with tardive dyskinesia whose pathophysiology has been related to oxidative stress. The present study was aimed to explore neuroprotective effects of nebivolol, an antihypertensive agent, on reserpine-induced neurobehavioral and biochemical alterations in rats. Reserpine (1 mg/kg, s.c.) was used to induce neurotoxicity. Administration of reserpine for 3 days every other day significantly increased the vacuous chewing movements (VCMs), tongue protrusions (TPs) and reduced the locomotor activity in rats. Pre-treatment with nebivolol (5 and 10 mg/kg, p.o. for 5 days) showed dose dependant decrease in VCMs and TP induced by reserpine. Nebivolol also showed significant improvement in locomotor activity. Reserpine significantly increased lipid peroxidation and reduced the levels of defensive antioxidant enzymes like catalase (CAT), superoxide dismutase (SOD) and reduced glutathione (GSH) in rat brain. Nebivolol reversed these effects of reserpine on oxidative stress indices; indicating amelioration of oxidative stress in rat brains. The results of the present study indicated that nebivolol has a protective role against reserpine-induced orofacial dyskinesia. Thus, the use of nebivolol as a therapeutic agent for the treatment of tardive dyskinesia may be considered." @default.
- W2040981010 created "2016-06-24" @default.
- W2040981010 creator A5006650385 @default.
- W2040981010 creator A5037132682 @default.
- W2040981010 creator A5043205822 @default.
- W2040981010 creator A5047744886 @default.
- W2040981010 creator A5083338881 @default.
- W2040981010 date "2013-10-01" @default.
- W2040981010 modified "2023-10-17" @default.
- W2040981010 title "Protective effect of nebivolol on reserpine-induced neurobehavioral and biochemical alterations in rats" @default.
- W2040981010 cites W1775749144 @default.
- W2040981010 cites W1825808183 @default.
- W2040981010 cites W1964087192 @default.
- W2040981010 cites W1964156528 @default.
- W2040981010 cites W1967443141 @default.
- W2040981010 cites W1983500350 @default.
- W2040981010 cites W1993149181 @default.
- W2040981010 cites W1995602802 @default.
- W2040981010 cites W1999781152 @default.
- W2040981010 cites W2003321649 @default.
- W2040981010 cites W2006370393 @default.
- W2040981010 cites W2010565561 @default.
- W2040981010 cites W2016293448 @default.
- W2040981010 cites W2018124968 @default.
- W2040981010 cites W2021755672 @default.
- W2040981010 cites W2025543510 @default.
- W2040981010 cites W2032681073 @default.
- W2040981010 cites W2057880195 @default.
- W2040981010 cites W2065372299 @default.
- W2040981010 cites W2067141570 @default.
- W2040981010 cites W2067825199 @default.
- W2040981010 cites W2071022372 @default.
- W2040981010 cites W2073687920 @default.
- W2040981010 cites W2075778298 @default.
- W2040981010 cites W2085518524 @default.
- W2040981010 cites W2087325346 @default.
- W2040981010 cites W2123297201 @default.
- W2040981010 cites W2146911942 @default.
- W2040981010 cites W2154831591 @default.
- W2040981010 cites W2160622942 @default.
- W2040981010 cites W226368818 @default.
- W2040981010 cites W2326200998 @default.
- W2040981010 cites W7213480 @default.
- W2040981010 doi "https://doi.org/10.1016/j.neuint.2013.07.002" @default.
- W2040981010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23871717" @default.
- W2040981010 hasPublicationYear "2013" @default.
- W2040981010 type Work @default.
- W2040981010 sameAs 2040981010 @default.
- W2040981010 citedByCount "17" @default.
- W2040981010 countsByYear W20409810102014 @default.
- W2040981010 countsByYear W20409810102015 @default.
- W2040981010 countsByYear W20409810102016 @default.
- W2040981010 countsByYear W20409810102017 @default.
- W2040981010 countsByYear W20409810102018 @default.
- W2040981010 countsByYear W20409810102020 @default.
- W2040981010 countsByYear W20409810102022 @default.
- W2040981010 crossrefType "journal-article" @default.
- W2040981010 hasAuthorship W2040981010A5006650385 @default.
- W2040981010 hasAuthorship W2040981010A5037132682 @default.
- W2040981010 hasAuthorship W2040981010A5043205822 @default.
- W2040981010 hasAuthorship W2040981010A5047744886 @default.
- W2040981010 hasAuthorship W2040981010A5083338881 @default.
- W2040981010 hasConcept C118552586 @default.
- W2040981010 hasConcept C126322002 @default.
- W2040981010 hasConcept C134018914 @default.
- W2040981010 hasConcept C181199279 @default.
- W2040981010 hasConcept C185592680 @default.
- W2040981010 hasConcept C25498285 @default.
- W2040981010 hasConcept C2775838275 @default.
- W2040981010 hasConcept C2776151105 @default.
- W2040981010 hasConcept C2776412080 @default.
- W2040981010 hasConcept C2777537511 @default.
- W2040981010 hasConcept C2777842393 @default.
- W2040981010 hasConcept C2779134260 @default.
- W2040981010 hasConcept C2779158372 @default.
- W2040981010 hasConcept C2779734285 @default.
- W2040981010 hasConcept C2780405171 @default.
- W2040981010 hasConcept C2780829032 @default.
- W2040981010 hasConcept C538909803 @default.
- W2040981010 hasConcept C55493867 @default.
- W2040981010 hasConcept C71924100 @default.
- W2040981010 hasConcept C84393581 @default.
- W2040981010 hasConcept C98274493 @default.
- W2040981010 hasConceptScore W2040981010C118552586 @default.
- W2040981010 hasConceptScore W2040981010C126322002 @default.
- W2040981010 hasConceptScore W2040981010C134018914 @default.
- W2040981010 hasConceptScore W2040981010C181199279 @default.
- W2040981010 hasConceptScore W2040981010C185592680 @default.
- W2040981010 hasConceptScore W2040981010C25498285 @default.
- W2040981010 hasConceptScore W2040981010C2775838275 @default.
- W2040981010 hasConceptScore W2040981010C2776151105 @default.
- W2040981010 hasConceptScore W2040981010C2776412080 @default.
- W2040981010 hasConceptScore W2040981010C2777537511 @default.
- W2040981010 hasConceptScore W2040981010C2777842393 @default.
- W2040981010 hasConceptScore W2040981010C2779134260 @default.
- W2040981010 hasConceptScore W2040981010C2779158372 @default.
- W2040981010 hasConceptScore W2040981010C2779734285 @default.
- W2040981010 hasConceptScore W2040981010C2780405171 @default.