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• W2041223976 abstract "Many herpesvirus-encoded protein kinases facilitate viral lytic replication. Importantly, the role of viral kinases in herpesvirus latency is less clear. Mouse gammaherpesvirus-68 (MHV68)-encoded protein kinase orf36 facilitates lytic replication in part through activation of the host DNA damage response (DDR). Here we show that MHV68 latency was attenuated in the absence of orf36 expression. Unexpectedly, our study uncovered enzymatic activity-independent role of orf36 in the establishment of MHV68 latency following intraperitoneal route of infection. H2AX, an important DDR protein, facilitates MHV68 lytic replication and may be directly phosphorylated by orf36 during lytic infection. In this study, H2AX deficiency, whether systemic or limited to infected cells, attenuated the establishment of MHV68 latency in vivo. Thus, our work reveals viral kinase-dependent regulation of gammaherpesvirus latency and illuminates a novel link between H2AX, a component of a tumor suppressor DDR network, and in vivo latency of a cancer-associated gammaherpesvirus." @default.
• W2041223976 created "2016-06-24" @default.
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• W2041223976 date "2010-09-01" @default.
• W2041223976 modified "2023-10-16" @default.
• W2041223976 title "Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo" @default.
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• W2041223976 doi "https://doi.org/10.1016/j.virol.2010.05.027" @default.
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