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- W2041808159 endingPage "986" @default.
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- W2041808159 abstract "Previously, we have identified the RUNX1 gene as hypomethylated and overexpressed in post-chemotherapy (CT) primary cultures derived from epithelial ovarian cancer (EOC) patients, when compared with primary cultures derived from matched primary (prior to CT) tumors. Here we show that RUNX1 displays a trend of hypomethylation, although not significant, in omental metastases compared with primary EOC tumors. Surprisingly, RUNX1 displayed significantly higher expression not only in metastatic tissue, but also in high-grade primary tumors and even in low malignant potential tumors. The RUNX1 expression levels were almost identical in primary tumors and omental metastases, suggesting that RUNX1 hypomethylation might have a limited impact on its overexpression in advanced (metastatic) stage of the disease. Knockdown of the RUNX1 expression in EOC cells led to sharp decrease of cell proliferation and induced G1 cell cycle arrest. Moreover, RUNX1 suppression significantly inhibited EOC cell migration and invasion. Gene expression profiling and consecutive network and pathway analyses confirmed these findings, as numerous genes and pathways known previously to be implicated in ovarian tumorigenesis, including EOC tumor invasion and metastasis, were found to be downregulated upon RUNX1 suppression, while a number of pro-apoptotic genes and some EOC tumor suppressor genes were induced. Taken together, our data are indicative for a strong oncogenic potential of the RUNX1 gene in EOC progression and suggest that RUNX1 might be a novel EOC therapeutic target. Further studies are needed to more completely elucidate the functional implications of RUNX1 and other members of the RUNX gene family in ovarian tumorigenesis." @default.
- W2041808159 created "2016-06-24" @default.
- W2041808159 creator A5019869174 @default.
- W2041808159 creator A5022422757 @default.
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- W2041808159 creator A5049133404 @default.
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- W2041808159 creator A5080765039 @default.
- W2041808159 creator A5087341200 @default.
- W2041808159 creator A5091028771 @default.
- W2041808159 date "2013-02-26" @default.
- W2041808159 modified "2023-10-02" @default.
- W2041808159 title "The RUNX1 transcription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell proliferation, migration and invasion" @default.
- W2041808159 cites W1443307322 @default.
- W2041808159 cites W1499523727 @default.
- W2041808159 cites W1520664789 @default.
- W2041808159 cites W1531183551 @default.
- W2041808159 cites W1861200333 @default.
- W2041808159 cites W1964644808 @default.
- W2041808159 cites W1968710298 @default.
- W2041808159 cites W1970698543 @default.
- W2041808159 cites W1972908866 @default.
- W2041808159 cites W1973023394 @default.
- W2041808159 cites W1983359126 @default.
- W2041808159 cites W1985346881 @default.
- W2041808159 cites W1986910294 @default.
- W2041808159 cites W1987593483 @default.
- W2041808159 cites W1990532910 @default.
- W2041808159 cites W1991535475 @default.
- W2041808159 cites W1992125584 @default.
- W2041808159 cites W1997140903 @default.
- W2041808159 cites W1998345728 @default.
- W2041808159 cites W2000188986 @default.
- W2041808159 cites W2003217138 @default.
- W2041808159 cites W2005583629 @default.
- W2041808159 cites W2007984671 @default.
- W2041808159 cites W2016140258 @default.
- W2041808159 cites W2017560111 @default.
- W2041808159 cites W2028747133 @default.
- W2041808159 cites W2031404063 @default.
- W2041808159 cites W2032091934 @default.
- W2041808159 cites W2035898873 @default.
- W2041808159 cites W2038315117 @default.
- W2041808159 cites W2038569516 @default.
- W2041808159 cites W2040380803 @default.
- W2041808159 cites W2041184836 @default.
- W2041808159 cites W2049679161 @default.
- W2041808159 cites W2053823503 @default.
- W2041808159 cites W2054033132 @default.
- W2041808159 cites W2057317196 @default.
- W2041808159 cites W2067513233 @default.
- W2041808159 cites W2068186422 @default.
- W2041808159 cites W2070120800 @default.
- W2041808159 cites W2074478596 @default.
- W2041808159 cites W2076558450 @default.
- W2041808159 cites W2076877350 @default.
- W2041808159 cites W2079466805 @default.
- W2041808159 cites W2079647316 @default.
- W2041808159 cites W2080302060 @default.
- W2041808159 cites W2082376546 @default.
- W2041808159 cites W2083243179 @default.
- W2041808159 cites W2083792932 @default.
- W2041808159 cites W2084290625 @default.
- W2041808159 cites W2085033687 @default.
- W2041808159 cites W2090918533 @default.
- W2041808159 cites W2092194090 @default.
- W2041808159 cites W2093588238 @default.
- W2041808159 cites W2095416597 @default.
- W2041808159 cites W2096674608 @default.
- W2041808159 cites W2104500108 @default.
- W2041808159 cites W2113833510 @default.
- W2041808159 cites W2122058106 @default.
- W2041808159 cites W2132244795 @default.
- W2041808159 cites W2140009101 @default.
- W2041808159 cites W2141410747 @default.
- W2041808159 cites W2142432567 @default.
- W2041808159 cites W2142438434 @default.
- W2041808159 cites W2145083591 @default.
- W2041808159 cites W2146616472 @default.
- W2041808159 cites W2148582994 @default.
- W2041808159 cites W2150136461 @default.
- W2041808159 cites W2150757282 @default.
- W2041808159 cites W2152731121 @default.
- W2041808159 cites W2153316451 @default.
- W2041808159 cites W2154544743 @default.
- W2041808159 cites W2155884268 @default.
- W2041808159 cites W2156156861 @default.
- W2041808159 cites W2158734599 @default.
- W2041808159 cites W2161612338 @default.
- W2041808159 cites W2162900557 @default.
- W2041808159 cites W2164286911 @default.
- W2041808159 cites W2167717154 @default.
- W2041808159 cites W2170635669 @default.
- W2041808159 cites W2321501864 @default.
- W2041808159 cites W3028515504 @default.
- W2041808159 cites W4250969231 @default.
- W2041808159 cites W4251845825 @default.