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• W2042772094 abstract "Fetal rat brown adipocytes show a low number of transforming growth factor β 1 (TGF‐ β 1 ) binding sites of high affinity, revealing the presence of type I, II and IIITGF‐ β 1 receptors and a minor‐labeled species of approximately 140 kDa. The culture of cells in the presence ofTGF‐ β 1 induced the expression of the tissue‐specific gene uncoupling protein in a dose‐ and time‐dependent manner. In addition,TGF‐ β 1 up‐regulates the expression of genes involved in adipogenesis such as fatty acid synthase, glycerol 3‐phosphate dehydrogenase, malic enzyme and glucose 6‐phosphate dehydrogenase, as well as induces the expression of fibronectin (specific target gene forTGF‐ β 1 ). Our results suggest thatTGF‐ β 1 is a major signal involved in initiating and/or maintaining the thermogenic and adipogenic differentiation of rat fetal brown adipocytes." @default.
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• W2042772094 date "1995-05-08" @default.
• W2042772094 modified "2023-10-14" @default.
• W2042772094 title "Transforming growth factor<i>β</i>₁induces differentiation-specific gene expression in fetal rat brown adipocytes" @default.
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• W2042772094 doi "https://doi.org/10.1016/0014-5793(95)00385-m" @default.
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