FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2042804590> ?p ?o ?g. }

• W2042804590 endingPage "1255" @default.
• W2042804590 startingPage "1241" @default.
• W2042804590 abstract "Abstract Human adipose-derived stromal cells (hASCs) have a proven capacity to aid in osseous repair of calvarial defects. However, the bone defect microenvironment necessary for osseous healing is not fully understood. In this study, we postulated that the cell-cell interaction between engrafted ASCs and host dura mater (DM) cells is critical for the healing of calvarial defects. hASCs were engrafted into critical sized calvarial mouse defects. The DM-hASC interaction was manipulated surgically by DM removal or by insertion of a semipermeable or nonpermeable membrane between DM and hASCs. Radiographic, histologic, and gene expression analyses were performed. Next, the hASC-DM interaction is assessed by conditioned media (CM) and coculture assays. Finally, bone morphogenetic protein (BMP) signaling from DM was investigated in vivo using novel BMP-2 and anti-BMP-2/4 slow releasing scaffolds. With intact DM, osseous healing occurs both from host DM and engrafted hASCs. Interference with the DM-hASC interaction dramatically reduced calvarial healing with abrogated BMP-2–Smad-1/5 signaling. Using CM and coculture assays, mouse DM cells stimulated hASC osteogenesis via BMP signaling. Through in vivo manipulation of the BMP-2 pathway, we found that BMP-2 plays an important role in DM stimulation of hASC osteogenesis in the context of calvarial bone healing. BMP-2 supplementation to a defect with disrupted DM allowed for bone formation in a nonhealing defect. DM is an osteogenic cell type that both participates in and stimulates osseous healing in a hASC-engrafted calvarial defect. Furthermore, DM-derived BMP-2 paracrine stimulation appears to play a key role for hASC mediated repair." @default.
• W2042804590 created "2016-06-24" @default.
• W2042804590 creator A5005728573 @default.
• W2042804590 creator A5029107105 @default.
• W2042804590 creator A5029427429 @default.
• W2042804590 creator A5038063552 @default.
• W2042804590 creator A5040238984 @default.
• W2042804590 creator A5063708863 @default.
• W2042804590 creator A5064932750 @default.
• W2042804590 creator A5080524079 @default.
• W2042804590 creator A5082290226 @default.
• W2042804590 creator A5085683951 @default.
• W2042804590 date "2011-07-26" @default.
• W2042804590 modified "2023-10-11" @default.
• W2042804590 title "Dura Mater Stimulates Human Adipose-Derived Stromal Cells to Undergo Bone Formation in Mouse Calvarial Defects" @default.
• W2042804590 cites W1663371441 @default.
• W2042804590 cites W1666061892 @default.
• W2042804590 cites W1964433813 @default.
• W2042804590 cites W1967341011 @default.
• W2042804590 cites W1968816076 @default.
• W2042804590 cites W1977025966 @default.
• W2042804590 cites W1980955678 @default.
• W2042804590 cites W1984956442 @default.
• W2042804590 cites W1985177804 @default.
• W2042804590 cites W1985942181 @default.
• W2042804590 cites W1985952359 @default.
• W2042804590 cites W1986763776 @default.
• W2042804590 cites W1989194294 @default.
• W2042804590 cites W1993722891 @default.
• W2042804590 cites W1996115570 @default.
• W2042804590 cites W1999817786 @default.
• W2042804590 cites W2000994952 @default.
• W2042804590 cites W2003649275 @default.
• W2042804590 cites W2003717884 @default.
• W2042804590 cites W2004617157 @default.
• W2042804590 cites W2006743860 @default.
• W2042804590 cites W2007409890 @default.
• W2042804590 cites W2009773280 @default.
• W2042804590 cites W2009850557 @default.
• W2042804590 cites W2011154167 @default.
• W2042804590 cites W2013200752 @default.
• W2042804590 cites W2013283437 @default.
• W2042804590 cites W2016091065 @default.
• W2042804590 cites W2017295059 @default.
• W2042804590 cites W2019191321 @default.
• W2042804590 cites W2020643835 @default.
• W2042804590 cites W2022055242 @default.
• W2042804590 cites W2032441881 @default.
• W2042804590 cites W2033291406 @default.
• W2042804590 cites W2036383343 @default.
• W2042804590 cites W2044760997 @default.
• W2042804590 cites W2046637649 @default.
• W2042804590 cites W2050433368 @default.
• W2042804590 cites W2051428145 @default.
• W2042804590 cites W2051559744 @default.
• W2042804590 cites W2051869462 @default.
• W2042804590 cites W2054615339 @default.
• W2042804590 cites W2057425253 @default.
• W2042804590 cites W2059509871 @default.
• W2042804590 cites W2063998346 @default.
• W2042804590 cites W2065704432 @default.
• W2042804590 cites W2073184155 @default.
• W2042804590 cites W2074395982 @default.
• W2042804590 cites W2078137073 @default.
• W2042804590 cites W2078237849 @default.
• W2042804590 cites W2080904393 @default.
• W2042804590 cites W2081014102 @default.
• W2042804590 cites W2086059908 @default.
• W2042804590 cites W2086642989 @default.
• W2042804590 cites W2087094815 @default.
• W2042804590 cites W2091513271 @default.
• W2042804590 cites W2093003043 @default.
• W2042804590 cites W2101431584 @default.
• W2042804590 cites W2102169821 @default.
• W2042804590 cites W2110222807 @default.
• W2042804590 cites W2120472195 @default.
• W2042804590 cites W2121551386 @default.
• W2042804590 cites W2126813006 @default.
• W2042804590 cites W2129292492 @default.
• W2042804590 cites W2137256580 @default.
• W2042804590 cites W2150326333 @default.
• W2042804590 cites W2154330374 @default.
• W2042804590 cites W2163503909 @default.
• W2042804590 cites W2165715446 @default.
• W2042804590 cites W2335577390 @default.
• W2042804590 cites W2967206079 @default.
• W2042804590 cites W4244352474 @default.
• W2042804590 cites W55998601 @default.
• W2042804590 cites W96119864 @default.
• W2042804590 doi "https://doi.org/10.1002/stem.670" @default.
• W2042804590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4353733" @default.
• W2042804590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21656608" @default.
• W2042804590 hasPublicationYear "2011" @default.
• W2042804590 type Work @default.
• W2042804590 sameAs 2042804590 @default.
• W2042804590 citedByCount "92" @default.
• W2042804590 countsByYear W20428045902012 @default.
• W2042804590 countsByYear W20428045902013 @default.

• next