Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043210008> ?p ?o ?g. }
- W2043210008 endingPage "4404" @default.
- W2043210008 startingPage "4399" @default.
- W2043210008 abstract "4-Amino-2-phenylquinazolines 7 were designed as bioisosteres of 3-arylisoquinolinamines 6 that were energy minimized to provide stable conformers. Interestingly, the 2-phenyl ring of 4-amino-2-phenylquinazolines was parallel to the quinazoline ring and improved their DNA intercalation ability in the DNA-topo I complex. Among the synthesized 4-amino group-substituted analogs, 4-cyclohexylamino-2-phenylquinazoline 7h exhibited potent topo I inhibitory activity and strong cytotoxicity. Interestingly, consistency was observed between the cytotoxicities and topo I activities in these quinazoline analogs, suggesting that the target of 4-amino-2-phenylquinazolines is limited to topo I. Molecular docking studies were performed with the Surflex-Dock program to afford the ideal interaction mode of the compound into the binding site of the DNA-topo I complex in order to clarify the topo I activity of 7h." @default.
- W2043210008 created "2016-06-24" @default.
- W2043210008 creator A5009590263 @default.
- W2043210008 creator A5017890721 @default.
- W2043210008 creator A5019128485 @default.
- W2043210008 creator A5046342467 @default.
- W2043210008 creator A5047995856 @default.
- W2043210008 creator A5057284798 @default.
- W2043210008 creator A5061566752 @default.
- W2043210008 creator A5062543970 @default.
- W2043210008 creator A5072378502 @default.
- W2043210008 date "2011-07-01" @default.
- W2043210008 modified "2023-09-27" @default.
- W2043210008 title "Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling" @default.
- W2043210008 cites W1969393767 @default.
- W2043210008 cites W1981630937 @default.
- W2043210008 cites W1982452627 @default.
- W2043210008 cites W1991414706 @default.
- W2043210008 cites W1993570389 @default.
- W2043210008 cites W1994240050 @default.
- W2043210008 cites W2005948990 @default.
- W2043210008 cites W2008110748 @default.
- W2043210008 cites W2009323563 @default.
- W2043210008 cites W2019672150 @default.
- W2043210008 cites W2038692006 @default.
- W2043210008 cites W2041796440 @default.
- W2043210008 cites W2047956764 @default.
- W2043210008 cites W2071975065 @default.
- W2043210008 cites W2073781949 @default.
- W2043210008 cites W2075357854 @default.
- W2043210008 cites W2079076987 @default.
- W2043210008 cites W2088675477 @default.
- W2043210008 cites W2102345056 @default.
- W2043210008 cites W2113413291 @default.
- W2043210008 cites W2129553158 @default.
- W2043210008 cites W2173336928 @default.
- W2043210008 cites W2173515523 @default.
- W2043210008 cites W2174610711 @default.
- W2043210008 cites W2951859542 @default.
- W2043210008 cites W4236530034 @default.
- W2043210008 doi "https://doi.org/10.1016/j.bmc.2011.05.012" @default.
- W2043210008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21684168" @default.
- W2043210008 hasPublicationYear "2011" @default.
- W2043210008 type Work @default.
- W2043210008 sameAs 2043210008 @default.
- W2043210008 citedByCount "14" @default.
- W2043210008 countsByYear W20432100082012 @default.
- W2043210008 countsByYear W20432100082013 @default.
- W2043210008 countsByYear W20432100082014 @default.
- W2043210008 countsByYear W20432100082015 @default.
- W2043210008 countsByYear W20432100082018 @default.
- W2043210008 countsByYear W20432100082020 @default.
- W2043210008 countsByYear W20432100082021 @default.
- W2043210008 countsByYear W20432100082022 @default.
- W2043210008 crossrefType "journal-article" @default.
- W2043210008 hasAuthorship W2043210008A5009590263 @default.
- W2043210008 hasAuthorship W2043210008A5017890721 @default.
- W2043210008 hasAuthorship W2043210008A5019128485 @default.
- W2043210008 hasAuthorship W2043210008A5046342467 @default.
- W2043210008 hasAuthorship W2043210008A5047995856 @default.
- W2043210008 hasAuthorship W2043210008A5057284798 @default.
- W2043210008 hasAuthorship W2043210008A5061566752 @default.
- W2043210008 hasAuthorship W2043210008A5062543970 @default.
- W2043210008 hasAuthorship W2043210008A5072378502 @default.
- W2043210008 hasConcept C109316439 @default.
- W2043210008 hasConcept C137824038 @default.
- W2043210008 hasConcept C147897179 @default.
- W2043210008 hasConcept C159110408 @default.
- W2043210008 hasConcept C178790620 @default.
- W2043210008 hasConcept C178910836 @default.
- W2043210008 hasConcept C185592680 @default.
- W2043210008 hasConcept C18705241 @default.
- W2043210008 hasConcept C202751555 @default.
- W2043210008 hasConcept C21951064 @default.
- W2043210008 hasConcept C2778866207 @default.
- W2043210008 hasConcept C2780378348 @default.
- W2043210008 hasConcept C32909587 @default.
- W2043210008 hasConcept C41685203 @default.
- W2043210008 hasConcept C515207424 @default.
- W2043210008 hasConcept C552990157 @default.
- W2043210008 hasConcept C55493867 @default.
- W2043210008 hasConcept C71240020 @default.
- W2043210008 hasConcept C71924100 @default.
- W2043210008 hasConceptScore W2043210008C109316439 @default.
- W2043210008 hasConceptScore W2043210008C137824038 @default.
- W2043210008 hasConceptScore W2043210008C147897179 @default.
- W2043210008 hasConceptScore W2043210008C159110408 @default.
- W2043210008 hasConceptScore W2043210008C178790620 @default.
- W2043210008 hasConceptScore W2043210008C178910836 @default.
- W2043210008 hasConceptScore W2043210008C185592680 @default.
- W2043210008 hasConceptScore W2043210008C18705241 @default.
- W2043210008 hasConceptScore W2043210008C202751555 @default.
- W2043210008 hasConceptScore W2043210008C21951064 @default.
- W2043210008 hasConceptScore W2043210008C2778866207 @default.
- W2043210008 hasConceptScore W2043210008C2780378348 @default.
- W2043210008 hasConceptScore W2043210008C32909587 @default.
- W2043210008 hasConceptScore W2043210008C41685203 @default.
- W2043210008 hasConceptScore W2043210008C515207424 @default.