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• W2043522433 abstract "We report new examples of lipoic acid (LA)–peptide conjugates, their potential as codrugs having anti-melanogenic and anti-aging properties was evaluated. These multifunctional molecules were prepared by linking lipophilic moiety (LA) to the pentapeptide KTTKS. The inhibitory effect of LA–peptide conjugates on melanin synthesis and tyrosinase activity is stronger than that of LA or the pentapeptide alone. Importantly, the conjugates display no cytotoxicity at a high concentration. LA–KTTKS and LA–PEG–KTTKS also inhibit UV-induced matrix metalloproteinase-1 expression up to 49.5% and 69.5% at 0.5 mM, respectively. LA–peptide conjugates stimulate collagen biosynthesis in fibroblasts more efficiently than their parent molecules do. These data suggest that LA–peptide conjugates may have cosmeceutical application as anti-melanogenic and anti-aging agents." @default.
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• W2043522433 date "2013-11-01" @default.
• W2043522433 modified "2023-09-27" @default.
• W2043522433 title "Synthesis of lipoic acid–peptide conjugates and their effect on collagen and melanogenesis" @default.
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• W2043522433 doi "https://doi.org/10.1016/j.ejmech.2013.09.011" @default.
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