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- W2044957020 endingPage "CMENT.S5129" @default.
- W2044957020 startingPage "CMENT.S5129" @default.
- W2044957020 abstract "EGFR belongs to the ErbB family of receptor tyrosine kinases and is associated with worse prognosis in head and neck squamous cell carcinoma (HNSCC). Cetuximab is a monoclonal antibody to the extracellular domain of EGFR and inhibits its downstream actions via multiple mechanisms. Besides its proven efficacy in locally advanced and incurable HNSCC, cetuximab has the distinct advantage of having a relatively tolerable side effect profile and not potentiating radiation toxicity. Though therapies for advanced HNSCC are evolving, locoregional recurrence and/or distant metastases occur in a large percentage of patients. Though some patients can be salvaged with surgery or radiation therapy, the majority are incurable, and are treated palliatively with systemic therapy. In the setting of first line therapy for recurrent/metastatic HNSCC, the EXTREME trial provided level 1 evidence that cetuximab improves overall survival when combined with cisplatinum and 5 FU. Following progression on first line chemotherapy, several phase II trials suggest that cetuximab monotherapy is a reasonable choice in this setting. Future studies should concentrate on clinical and molecular markers that may allow more personalized approaches to treating HNSCC, and combining EGFR inhibitors with other agents in a synergistic approach." @default.
- W2044957020 created "2016-06-24" @default.
- W2044957020 creator A5001336339 @default.
- W2044957020 creator A5053602981 @default.
- W2044957020 creator A5079982098 @default.
- W2044957020 date "2012-01-01" @default.
- W2044957020 modified "2023-10-15" @default.
- W2044957020 title "Treatment of Recurrent Metastatic Head and Neck Cancer: Focus on Cetuximab" @default.
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