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- W2045102991 abstract "It is currently discussed if beta-blockers exert harmful effects and increase mortality in patients with cirrhosis and refractory ascites. In this study, we provide an overview of the available literature in this field in combination with a retrospective analysis of 61 patients with cirrhosis and refractory ascites in a tertiary unit.We performed a systematic search of literature in May 2014. In addition, 61 patients with cirrhosis and ascites were identified and followed from development of refractory ascites until death or end of follow-up.Fourteen trials (9 trials on propranolol, 1 case-control study and 4 retrospective analyses) were identified. One trial suggested an increased mortality in patients treated with beta-blockers and refractory ascites. The results of the remaining trials were inconclusive. No increase in mortality among beta-blocker-treated patients was found in the present retrospective analysis.Treatment with beta-blockers may increase mortality in patients with cirrhosis and refractory ascites. However, the current evidence is sparse and high-quality studies are warranted to clarify the matter." @default.
- W2045102991 created "2016-06-24" @default.
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- W2045102991 date "2014-08-12" @default.
- W2045102991 modified "2023-10-18" @default.
- W2045102991 title "Beta-blockers in cirrhosis and refractory ascites: a retrospective cohort study and review of the literature" @default.
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- W2045102991 doi "https://doi.org/10.3109/00365521.2014.948053" @default.
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